Pharmacokinetic and biodistribution studies of doxorubicin-loaded single-wall carbon nanohorns in mice

被引：0

作者：

Wang, Junling ^{[1
]}

Ma, Xiaona ^{[2
]}

Shu, Chang ^{[1
]}

Li, Nannan ^{[1
]}

Zhao, Qian ^{[1
]}

Wang, Ran ^{[1
]}

Zhong, Wenying ^{[1
,3
]}

机构：

[1] China Pharmaceut Univ, Dept Analyt Chem, Nanjing, Jiangsu, Peoples R China

[2] Hohai Univ, Coll Environm, Key Lab Integrated Regulat & Resource Dev Shallow, Minist Educ, Nanjing 210098, Jiangsu, Peoples R China

[3] China Pharmaceut Univ, Key Lab Biomed Funct Mat, Nanjing 210009, Jiangsu, Peoples R China

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2015年 / 17卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Doxorubicin; Single-wall carbon nanohorns; Pharmacokinetic; Biodistribution; Nanotoxicity; Nanomedicine; PEGYLATED LIPOSOMAL DOXORUBICIN; IN-VIVO; MACROMOLECULAR THERAPEUTICS; CANCER-CHEMOTHERAPY; POROSITY EVALUATION; NANOTUBES; TOXICITY; TISSUES; CARDIOTOXICITY; FORMULATIONS;

D O I：

10.1007/s11051-015-3184-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pharmacokinetic and biodistribution studies of doxorubicin-loaded carbon nanohorns (DOX@oxSWCNHs/SA) in plasma and tissues were carried out. A high-performance liquid chromatographic method was developed and validated to determine the amount of doxorubicin. Compared with free DOX, the half-life (t(1/2)) of DOX@oxSWCNHs/SA was increased from 5.44 +/- 1.09 to 7.38 +/- 0.98 h, area under plasma concentration-time curve (AUC(0-infinity)) was increased from 0.63 +/- 0.008 to 1.42 +/- 0.12 mu g/(ml h), and the clearance of DOX was declined from 634 +/- 10.05 to 280 +/- 24.06 ml/h. No DOX was detected in heart after intravenous injection with DOX@oxSWCNHs/SA, while higher concentrations of drug were found in other tissues. These results suggested that DOX@oxSWCNHs/SA had the potential to obtain a long retention time in blood, sustained drug release, and a low toxicity, especially low cardiotoxicity.

引用

页数：9

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