The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease

被引：38

作者：

van den Berge, M ^{[1
]}

Polosa, R ^{[1
]}

Kerstjens, HAM ^{[1
]}

Postma, DS ^{[1
]}

机构：

[1] Univ Groningen Hosp, Dept Pulmonol, NL-9700 RB Groningen, Netherlands

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2004年 / 114卷 / 04期

关键词：

AMP; adenosine; hyperresponsiveness; inflammation;

D O I：

10.1016/j.jaci.2004.05.071

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Bronchial hyperresponsiveness is present in virtually all patients with asthma and in more than two thirds of patients with chronic obstructive pulmonary disease. Thus far, methacholine and histamine are usually used to measure bronchial hyperresponsiveness. Both are direct stimuli, because they act directly on airway smooth muscle. Another possible stimulus to measure bronchial hyperresponsiveness is AMP. AMP is an indirect stimulus, because it acts via the release of histamine and other mediators from immunologically primed mast cells. There is increasing interest in the role of AMP as a bronchoconstrictor stimulus because it has been suggested that the concentration of AMP causing the FEV1 to decrease by 20% (PC20 AMP) may be used as a noninvasive marker of airway inflammation. The aim of this article was to review the literature assessing AMP's value in asthma and chronic obstructive pulmonary disease.

引用

收藏

页码：737 / 746

页数：10

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