Analysis of Gene-Environment Interactions Related to Developmental Disorders

被引：5
作者：
Nishimura, Yuhei [1 ]
Kurosawa, Kenji [2 ,3 ]
机构：
[1] Mie Univ, Grad Sch Med, Dept Integrat Pharmacol, Tsu, Mie, Japan
[2] Kanagawa Childrens Med Ctr, Div Med Genet, Yokohama, Kanagawa, Japan
[3] Mie Univ, Grad Sch Med, Dept Clin Dysmorphol, Tsu, Mie, Japan
来源：
FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷
关键词：
developmental toxicity; gene-environment interaction; susceptibility; resilience; organoid; clinical genetics; COPY NUMBER VARIATION; MOLECULAR-MECHANISMS; LARGE-SCALE; ZEBRAFISH; RISK; IDENTIFICATION; MUTAGENESIS; RESILIENCE; METABOLISM; MUTATIONS;
D O I：
10.3389/fphar.2022.863664
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Various genetic and environmental factors are associated with developmental disorders (DDs). It has been suggested that interaction between genetic and environmental factors (G x E) is involved in the etiology of DDs. There are two major approaches to analyze the interaction: genome-wide and candidate gene-based approaches. In this mini-review, we demonstrate how these approaches can be applied to reveal the G x E related to DDs focusing on zebrafish and mouse models. We also discuss novel approaches to analyze the G x E associated with DDs.
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页数：7
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