Modification of Proteins by Metabolites in Immunity

被引：144

作者：

Diskin, C. ^{[1
]}

Ryan, T. A. J. ^{[1
]}

O'Neill, L. A. J. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst, Dublin, Ireland

来源：

IMMUNITY | 2021年 / 54卷 / 01期

关键词：

PYRUVATE-KINASE M2; DNA SENSOR CGAS; POSTTRANSLATIONAL MODIFICATION; SUCCINATE-DEHYDROGENASE; T-CELLS; CHEMICAL-MODIFICATION; HISTONE DEACETYLASES; LYSINE SUCCINYLATION; NLRP3; INFLAMMASOME; IL-1-BETA;

D O I：

10.1016/j.immuni.2020.09.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunometabolism has emerged as a key focus for immunologists, with metabolic change in immune cells becoming as important a determinant for specific immune effector responses as discrete signaling pathways. A key output for these changes involves post-translational modification (PTM) of proteins by metabolites. Products of glycolysis and Krebs cycle pathways can mediate these events, as can lipids, amino acids, and polyamines. A rich and diverse set of PTMs in macrophages and T cells has been uncovered, altering phenotype and modulating immunity and inflammation in different contexts. We review the recent findings in this area and speculate whether they could be of use in the effort to develop therapeutics for immune-related diseases.

引用

页码：19 / 31

页数：13

共 122 条

[1] S-(2-succinyl)cysteine:: A novel chemical modification of tissue proteins by a Krebs cycle intermediate [J].

Alderson, Nathan L. ;

Wang, Yuping ;

Blatnik, Matthew ;

Frizzell, Norma ;

Walla, Michael D. ;

Lyons, Timothy J. ;

Alt, Nadja ;

Carson, James A. ;

Nagai, Ryji ;

Thorpe, Suzanne R. ;

Baynes, John W. .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2006, 450 (01) :1-8

[2]

ALLAND L, 1994, J BIOL CHEM, V269, P16701

[3] Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity [J].

Angiari, Stefano ;

Runtsch, Marah C. ;

Sutton, Caroline E. ;

Palsson-McDermott, Eva M. ;

Kelly, Beth ;

Rana, Nisha ;

Kane, Harry ;

Papadopoulou, Gina ;

Pearce, Erika L. ;

Mills, Kingston H. G. ;

O'Neill, Luke A. J. .

CELL METABOLISM, 2020, 31 (02) :391-+

[4]

Artyomov H., 2020, COMP EVALUATION ITAC

[5] Memory CD8+ T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function [J].

Balmer, Maria L. ;

Ma, Eric H. ;

Bantug, Glenn R. ;

Grahlert, Jasmin ;

Pfister, Simona ;

Glatter, Timo ;

Jauch, Annaise ;

Dimeloe, Sarah ;

Slack, Emma ;

Dehio, Philippe ;

Krzyzaniak, Magdalena A. ;

King, Carolyn G. ;

Burgener, Anne-Valerie ;

Fischer, Marco ;

Develioglu, Leyla ;

Belle, Reka ;

Recher, Mike ;

Bonilla, Weldy V. ;

Macpherson, Andrew J. ;

Hapfelmeier, Siegfried ;

Jones, Russell G. ;

Hess, Christoph .

IMMUNITY, 2016, 44 (06) :1312-1324

[6] Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis [J].

Bambouskova, Monika ;

Gorvel, Laurent ;

Lampropoulou, Vicky ;

Sergushichev, Alexey ;

Loginicheva, Ekaterina ;

Johnson, Kendall ;

Korenfeld, Daniel ;

Mathyer, Mary Elizabeth ;

Kim, Hyeryun ;

Huang, Li-Hao ;

Duncan, Dustin ;

Bregman, Howard ;

Keskin, Abdurrahman ;

Santeford, Andrea ;

Apte, Rajendra S. ;

Sehgal, Raghav ;

Johnson, Britney ;

Amarasinghe, Gaya K. ;

Soares, Miguel P. ;

Satoh, Takashi ;

Akira, Shizuo ;

Hai, Tsonwin ;

Strong, Cristina de Guzman ;

Auclair, Karine ;

Roddy, Thomas P. ;

Biller, Scott A. ;

Jovanovic, Marko ;

Klechevsky, Eynav ;

Stewart, Kelly M. ;

Randolph, Gwendalyn J. ;

Artyomov, Maxim N. .

NATURE, 2018, 556 (7702) :501-+

[7] De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells [J].

Berod, Luciana ;

Friedrich, Christin ;

Nandan, Amrita ;

Freitag, Jenny ;

Hagemann, Stefanie ;

Harmrolfs, Kirsten ;

Sandouk, Aline ;

Hesse, Christina ;

Castro, Carla N. ;

Baehres, Heike ;

Tschirner, Sarah K. ;

Gorinski, Nataliya ;

Gohmert, Melanie ;

Mayer, Christian T. ;

Huehn, Jochen ;

Ponimaskin, Evgeni ;

Abraham, Wolf-Rainer ;

Mueller, Rolf ;

Lochner, Matthias ;

Sparwasser, Tim .

NATURE MEDICINE, 2014, 20 (11) :1327-1333

[8] Inactivation of glyceraldehyde-3-phosphate dehydrogenase by fumarate in diabetes - Formation of S-(2-succinyl)cysteine, a novel chemical modification of protein and possible biomarker of mitochondrial stress [J].

Blatnik, Matthew ;

Frizzell, Norma ;

Thorpe, Suzanne R. ;

Baynes, John W. .

DIABETES, 2008, 57 (01) :41-49

[9] BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation [J].

Bononi, Angela ;

Giorgi, Carlotta ;

Patergnani, Simone ;

Larson, David ;

Verbruggen, Kaitlyn ;

Tanji, Mika ;

Pellegrini, Laura ;

Signorato, Valentina ;

Olivetto, Federica ;

Pastorino, Sandra ;

Nasu, Masaki ;

Napolitano, Andrea ;

Gaudino, Giovanni ;

Morris, Paul ;

Sakamoto, Greg ;

Ferris, Laura K. ;

Danese, Alberto ;

Raimondi, Andrea ;

Tacchetti, Carlo ;

Kuchay, Shafi ;

Pass, Harvey I. ;

Affar, El Bachir ;

Yang, Haining ;

Pinton, Paolo ;

Carbone, Michele .

NATURE, 2017, 546 (7659) :549-+

[10] The Mammalian Malonyl-CoA Synthetase ACSF3 Is Required for Mitochondrial Protein Malonylation and Metabolic Efficiency [J].

Bowman, Caitlyn E. ;

Rodriguez, Susana ;

Alpergin, Ebru S. Selen ;

Acoba, Michelle G. ;

Zhao, Liang ;

Hartung, Thomas ;

Claypool, Steven M. ;

Watkins, Paul A. ;

Wolfgang, Michael J. .

CELL CHEMICAL BIOLOGY, 2017, 24 (06) :673-+

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