Synthesis of Functionalized Indoles via Palladium-Catalyzed Aerobic Oxidative Cycloisomerization of o-Allylanilines

被引：38

作者：

Nallagonda, Rajender ^{[1
]}

Rehan, Mohammad ^{[1
]}

Ghorai, Prasanta ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal 462066, India

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 18期

关键词：

ASSISTED INTRAMOLECULAR AMINATION; C BOND FORMATION; N-ARYL ENAMINES; MOLECULAR-OXYGEN; ALKALOIDS; ANILINES; ALKENES; CYCLIZATION; OLEFINS; AMINOPALLADATION;

D O I：

10.1021/ol502244g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient strategy for the synthesis of 3-substituted 2-benzylindoles from stable and readily available o-allylanilines, prepared from anilines and allyl alcohols, has been developed. The reaction occurred via a regioselective 5-exo-trig intramolecular oxidative cycloisomerization using Pd(OAc)(2) as catalyst and molecular oxygen as an oxidant. The reaction showed a broad substrate scope with good to excellent yields.

引用

收藏

页码：4786 / 4789

页数：4

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