Anti-inflammatory effects of diethylcarbamazine: A review

被引：31

作者：

Peixoto, Christina Alves ^{[1
]}

Silva, Bruna Santos ^{[1
]}

机构：

[1] Fundacao Oswaldo Cruz, Ctr Pesquisas Aggeu Magalhaes, Lab Ultraestrutura, BR-50670420 Recife, PE, Brazil

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2014年 / 734卷

关键词：

Diethylcarbamazine; Cyclooxygenase; Lipoxygenase; NF-kappa B; NITRIC-OXIDE SYNTHASE; TROPICAL PULMONARY EOSINOPHILIA; RESPIRATORY-TRACT INFLAMMATION; PLATELET-ACTIVATING-FACTOR; FACTOR-KAPPA-B; ONCHOCERCA-VOLVULUS; PHARMACOLOGICAL MODULATION; BRUGIA-MALAYI; GENE-THERAPY; INHIBITION;

D O I：

10.1016/j.ejphar.2014.03.046

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Diethylcarbamazine (DEC) interferes with cyclooxygenase and lipoxygenase pathways, reducing the production of thromboxane, prostacyclin, prostaglandin and leukotrienes. Recent studies using different experimental models of inflammation have indicated that DEC, in addition to inhibiting cyclooxygenase and lipoxygenase pathways, also inhibits nuclear transcription factor kappa B (NF-kappa B) activation, which is a key regulator of proinflammatory genes such as TNF-alpha, IL-1 beta, inducible nitric oxide synthase (iNOS) and even cyclooxygenase 2 (COX-2). The aim of the present study is to provide a comprehensive summary of DEC, including a description of filaricidal action, inhibition of synthesis and secretory pathways, immunomodulatory activity, and specific inhibition of lipoxygenase and cyclooxygenase pathways. Copyright (c) 2014 Elsevier B.V. All rights reserved.

引用

页码：35 / 41

页数：7

共 94 条

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