Regulatory T cells for tolerance

被引：78
|
作者：
Kawai, Kento [1 ]
Uchiyama, Masateru [1 ]
Hester, Joanna [1 ]
Wood, Kathryn [1 ]
Issa, Fadi [1 ]
机构：
[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg Sci, Transplantat Res Immunol Grp, Level 6, Oxford 0X3 9DU, England
来源：
HUMAN IMMUNOLOGY | 2018年 / 79卷 / 05期
基金：
英国医学研究理事会;
关键词：
Regulatory T cells; T cell; Tolerance; Immunosuppression; Humanized mouse; UMBILICAL-CORD BLOOD; TRANSCRIPTION FACTOR FOXP3; KIDNEY-TRANSPLANT RECIPIENTS; CHIMERIC ANTIGEN RECEPTOR; RENAL-ALLOGRAFT REJECTION; HUMANIZED MOUSE MODEL; VERSUS-HOST-DISEASE; IN-VIVO EXPANSION; EX-VIVO; ADOPTIVE TRANSFER;
D O I：
10.1016/j.humimm.2017.12.013
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation tolerance. Progress has now reached a critical threshold as techniques for production of clinical therapies are optimised and Phase I/II clinical trials are in full swing. Initial safety and efficacy data are being reported, with trials assessing a number of different strategies for the introduction of Treg therapy. It is now more crucial than ever to elucidate further the function and behaviour of Tregs in vivo and ensure safe delivery. This review will discuss the current state of the art and future directions in Treg therapy.
引用
收藏
页码：294 / 303
页数：10
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