Effect of ethylparaben on the growth and development of Drosophila melanogaster on preadult

被引：8
|
作者：
Gao, Lin [1 ]
Li, Yajuan [1 ]
Xie, Hongqin [1 ]
Wang, Yuan [1 ]
Zhao, Haizhen [1 ]
Zhang, Min [1 ]
Gu, Wei [1 ]
机构：
[1] Shaanxi Normal Univ, Coll Life Sci, 620 West Changan Ave, Xian 710119, Peoples R China
来源：
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2020年 / 80卷
关键词：
Ethylparaben; Drosophila melanogaster; Preadult; Development cycle; Juvenile hormone; 20-hydroxyecdysone; HYDROXYBENZOIC ACID-ESTERS; PERSONAL CARE PRODUCTS; JUVENILE-HORMONE; ECDYSONE RECEPTOR; PARABENS; ECR; METHYLPARABEN; METAMORPHOSIS; PROPYLPARABEN; TOXICITY;
D O I：
10.1016/j.etap.2020.103495
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Parabens are esters of p-hydroxybenzoic acid, including methylparaben (MP), ethylparaben (EP), propylparaben (PP), and the like. This substance has estrogenic and antiandrogenic effects, and a putative role in promoting cancer through endocrine disruption. By exposing Drosophila melanogaster to different concentrations of EP (300 mg/L, 700 mg/L, and 1000 mg/L), we investigated the effect of EP on the growth and development of D. melanogaster before emergence. We found that EP prolonged the development cycle of D. melanogaster, and changed the relative expression levels of Met, Gce, EcR, Kr-h1, and Br. In addition, EP reduced the titer of juvenile hormone III (JH III) and 20-hydroxyecdysone (20E), and delayed the peak of hormone secretion. This study provided a more objective and thorough assessment of safety for the parabens.
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页数：7
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