200 MeV Proton Radiography Studies With a Hand Phantom Using a Prototype Proton CT Scanner

被引：35

作者：

Plautz, Tia ^{[1
]}

Bashkirov, V. ^{[2
]}

Feng, V.

Hurley, F. ^{[2
]}

Johnson, R. P. ^{[1
]}

Leary, C. ^{[1
]}

Macafee, S. ^{[1
]}

Plumb, A. ^{[1
]}

Rykalin, V. ^{[4
]}

Sadrozinski, H. F. -W. ^{[1
]}

Schubert, K. ^{[3
]}

Schulte, R. ^{[2
]}

Schultze, B. ^{[3
]}

Steinberg, D. ^{[1
]}

Witt, M. ^{[3
]}

Zatserklyaniy, A. ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Santa Cruz Inst Particle Phys, Santa Cruz, CA 95064 USA

[2] Loma Linda Univ, Med Ctr, Loma Linda, CA 92354 USA

[3] Calif State Univ San Bernardino, San Bernardino, CA 92407 USA

[4] No Illinois Univ, Dept Phys, De Kalb, IL 60115 USA

来源：

IEEE TRANSACTIONS ON MEDICAL IMAGING | 2014年 / 33卷 / 04期

基金：

美国国家科学基金会;

关键词：

Data reduction; proton imaging; spatial resolution; tomographic reconstruction of material properties; COMPUTED-TOMOGRAPHY; STOPPING POWER; PATH; PATIENT;

D O I：

10.1109/TMI.2013.2297278

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

Proton radiography has applications in patient alignment and verification procedures for proton beam radiation therapy. In this paper, we report an experiment which used 200 MeV protons to generate proton energy-loss and scattering radiographs of a hand phantom. The experiment used the first-generation proton computed tomography (CT) scanner prototype, which was installed on the research beam line of the clinical proton synchrotron at Loma Linda University Medical Center. It was found that while both radiographs displayed anatomical details of the hand phantom, the energy-loss radiograph had a noticeably higher resolution. Nonetheless, scattering radiography may yield more contrast between soft and bone tissue than energy-loss radiography, however, this requires further study. This study contributes to the optimization of the performance of the next-generation of clinical proton CT scanners. Furthermore, it demonstrates the potential of proton imaging (proton radiography and CT), which is now within reach of becoming available as a new, potentially low-dose medical imaging modality.

引用

页码：875 / 881

页数：7

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