An expedient synthesis of oxazepino and oxazocino quinazolines

被引：10

作者：

Hensbergen, Albertus Wijnand ^{[1
]}

Mills, Vanessa R. ^{[1
]}

Collins, Ian ^{[2
]}

Jones, Alan M. ^{[1
]}

机构：

[1] Manchester Metropolitan Univ, Sch Sci & Environm, Div Chem & Environm Sci, Fac Sci & Engn, Manchester M1 5GD, Lancs, England

[2] Inst Canc Res, Canc Res UK Canc Therapeut Unit, Sutton SM2 5NG, Surrey, England

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 46期

关键词：

Niementowski reaction; Quinazoline; Heterocycle; Cyclisation; Medium-ring; KINASE INHIBITORS; ANTICANCER AGENTS; DERIVATIVES; HETEROCYCLES; AMINES; CANCER; CARBONYLATION; CLEAVAGE; BIOLOGY;

D O I：

10.1016/j.tetlet.2015.10.008

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring is reported. An expedient synthetic route involving nucleophilic aromatic substitution, and sequential Niementowski and BOP-mediated ring closures afforded a collection of analogues. The scope of the reaction was explored in terms of cyclic and acyclic linkers, ring size and substitution pattern. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：6478 / 6483

页数：6

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