Childhood trauma, depression and negative symptoms are independently associated with impaired quality of life in schizophrenia. Results from the national FACE-SZ cohort

被引：49

作者：

Andrianarisoa, M. ^{[3
,12
]}

Boyer, L. ^{[12
,15
]}

Godin, O. ^{[12
,20
,21
]}

Brunel, L. ^{[3
,12
]}

Bulzacka, E. ^{[3
,12
]}

Aouizerate, B. ^{[6
,12
,16
,18
]}

Berna, F. ^{[1
,12
]}

Capdevielle, D. ^{[4
,12
]}

Dorey, J. M. ^{[5
,12
]}

Dubertret, C. ^{[9
,12
]}

Dubreucq, J. ^{[8
,12
]}

Faget, C. ^{[10
,12
]}

Gabayet, F. ^{[8
,12
]}

Llorca, P. M. ^{[2
,12
]}

Mallet, J. ^{[9
,10
,12
]}

Misdrahi, D. ^{[6
,7
,12
,16
,19
]}

Rey, R. ^{[5
,12
]}

Richieri, R. ^{[12
]}

Passerieux, C. ^{[11
,12
,17
]}

Schandrin, A. ^{[4
,12
]}

Tronche, A. M. ^{[2
,12
]}

Urbach, M. ^{[11
,12
,17
]}

Vidailhet, P. ^{[1
,12
]}

Schurhoff, F. ^{[3
,12
]}

Fond, G. ^{[3
,12
,13
,14
,22
]}

Andrianarisoa, M. ^{[3
,12
]}

Aouizerate, B. ^{[6
,12
,16
,18
]}

Berna, F. ^{[1
,12
]}

Blanc, O. ^{[2
,12
]}

Brunel, L. ^{[3
,12
]}

Bulzacka, E. ^{[3
,12
]}

Capdevielle, D. ^{[4
,12
]}

Chereau-Boudet, I. ^{[2
,12
]}

Chesnoy-Servanin, G. ^{[5
,12
]}

Danion, J. M. ^{[1
,12
]}

D'Amato, T. ^{[5
,12
]}

Deloge, A. ^{[6
,7
,12
]}

Delorme, C. ^{[8
,12
]}

Denizot, H. ^{[2
,12
]}

Dorey, J. M. ^{[5
,12
]}

Dubertret, C. ^{[9
,12
]}

Dubreucq, J. ^{[8
,12
]}

Faget, C. ^{[10
,12
]}

Fluttaz, C. ^{[8
,12
]}

Fond, G. ^{[3
,12
,13
,14
,22
]}

Fonteneau, S. ^{[11
,12
]}

Gabayet, F. ^{[8
,12
]}

Giraud-Baro, E. ^{[8
,12
]}

Hardy-Bayle, M. C. ^{[11
,12
]}

Lacelle, D. ^{[2
,12
]}

机构：

[1] Univ Strasbourg, Hop Univ Strasbourg, INSERM, U1114,Federat Med Translat Strasbourg, Strasbourg, France

[2] Univ Auvergne, Fac Med, EA 7280, CMP B,CHU, BP 69, F-63003 Clermont Ferrand 1, France

[3] Univ Paris Est Creteil, Hop Univ H Mondor, AP HP,INSERM,U955, DHU Pe PSY,Pole Psychiat & Addictol,Eq Psychiat T, Creteil, France

[4] Univ Montpellier I, CHRU Montpellier, Hop Colombiere, Serv Univ Psychiat Adulte,Inserm 1061, Montpellier, France

[5] Univ Claude Bernard Lyon 1, Ctr Hosp Le Vinatier Pole Est, BP 300 39-95 Bd Pinel, F-69678 Bron, France

[6] Ctr Hosp Charles Perrens, F-33076 Bordeaux, France

[7] Univ Bordeaux, CNRS, UMR 5287, INCIA, Bordeaux, France

[8] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France

[9] Univ Paris Diderot, Sorbonne Paris Cite, Louis Mourier Hosp Colombes, AP HP,Dept Psychiat,Inserm,U894,Fac Med, Paris, France

[10] AP HM, Pole Univ Psychiat, Marseille, France

[11] Univ Versailles St Quentin Yvelines, UFR Sci Sante Simone Veil, Ctr Hosp Versailles, Serv Psychiat Adulte,EA 4047,HANDIReSP, Versailles, France

[12] Fdn Fondamental, Creteil, France

[13] Hop Prive Parisien, Clin Jeanne Arc, 55 Rue Commandant Mouchotte, F-94160 St Mande, France

[14] CHU Caremeau, F-30000 Nimes, France

[15] CHU St Marguerite, Pole Psychiat Univ, F-13274 Marseille 09, France

[16] Univ Bordeaux, Bordeaux, France

[17] Univ Versailles St Quentin Yvelines, UFR Sci Sante Simone Veil, Ctr Hosp Versailles, Serv Psychiat Adulte, Versailles, France

[18] INSERM, U862, Neuroctr Magendie, Physiopathol Plasticite Neuronale, F-33000 Bordeaux, France

[19] CNRS, UMR 5287, INCIA, Paris, France

[20] UPMC Univ Paris 06, Sorbonne Univ, UMR S 1136, Inst Pierre Louis Epidemiol & Sante Publ, F-75013 Paris, France

[21] INSERM, UMR S 1136, Inst Pierre Louis Epidemiol & Sante Publ, F-75013 Paris, France

[22] CHU Caremeau, Nimes, France

来源：

SCHIZOPHRENIA RESEARCH | 2017年 / 185卷

关键词：

Quality of life; Schizophrenia; Depression; Childhood trauma; Negative symptoms; RATING-SCALE; PSYCHOPATHOLOGY; NEUROCOGNITION; MALTREATMENT; INFLAMMATION; RELIABILITY; PSYCHOSIS; SELECTION; VALIDITY; CHILDREN;

D O I：

10.1016/j.schres.2016.12.021

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objectives: Depression and negative symptoms have been associated with impaired Quality of life (QoL) in schizophrenia (SZ). However, childhood trauma may influence both QoL and depression in SZ patients, with consequences for the management of impaired QoL in SZ patients. The aim of the present study was to determine if childhood trauma was associated with impaired QoL in schizophrenia. Method: A sample of 544 community-dwelling stabilized SZ patients enrolled in FACE-SZ cohort were utilized in this study (74.1% males, mean aged 32.3 years, mean illness duration 10.6 years). QoL was self-reported with the 5-QoL18 questionnaire. Childhood trauma was self-reported with the Childhood Trauma Questionnaire. Depression was measured by the Calgary Depression Rating Scale for Schizophrenia. Psychotic severity was measured by the Positive and Negative Syndrome Scale for Schizophrenia (PANSS). Other clinical factors, treatments, comorbidities, functioning and sociodemographical variables were also recorded, with validated scales. Results: Overall, 151 participants (27.8%) had a current major depressive episode and 406 (82.5%) reported at least one episode of historical childhood trauma. In multivariate analyses, lower QoL total score was associated with a history of childhood trauma (beta = -0.21, p < 0.0001), psychotic negative symptoms (beta -0.11, p = 0.04), current depression (beta = -0.0.38, p < 0.0001) and male gender (beta = -0.16, p < 0.0001). Conclusion: Impaired QoL is independently associated with negative symptoms, depression and childhood trauma in schizophrenia. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：173 / 181

页数：9

共 33 条

[1] RELIABILITY AND VALIDITY OF A DEPRESSION RATING-SCALE FOR SCHIZOPHRENICS [J].