Ellagic acid protects against diabetic nephropathy in rats by regulating the transcription and activity of Nrf2

被引：26

作者：

ALTamimi, Jozaa Z. ^{[1
]}

AlFaris, Nora A. ^{[1
]}

Alshammari, Ghedeir M. ^{[2
]}

Alagal, Reham, I ^{[1
]}

Aljabryn, Dalal H. ^{[1
]}

Aldera, Hussain ^{[3
,4
]}

Alrfaei, Bahauddeen M. ^{[4
]}

Alkhateeb, Mahmoud A. ^{[3
]}

Yahya, Mohammed A. ^{[2
]}

机构：

[1] Princess Nourah Bint Abdulrahman Univ, Dept Phys Sport Sci, Nutr & Food Sci, Riyadh, Saudi Arabia

[2] King Saud Univ, Coll Food & Agr Sci, Dept Food Sci & Nutr, Riyadh, Saudi Arabia

[3] King Saud bin Abdulaziz Univ Hlth Sci KSAU HS, Coll Med, Dept Basic Med Sci, Riyadh, Saudi Arabia

[4] King Saud Bin Abdulaziz Univ Hlth Sci KSAU HS, King Abdullah Int Res Ctr KAIMRC, Riyadh, Saudi Arabia

来源：

JOURNAL OF FUNCTIONAL FOODS | 2021年 / 79卷

关键词：

Ellagic acid; Diabetes; Nephropathy; Nrf2; Oxidative stress; Inflammation; NF-KAPPA-B; OXIDATIVE STRESS; HISTOLOGICAL-CHANGES; INSULIN-RESISTANCE; IN-VITRO; KIDNEY; DAMAGE; CELLS; DEGRADATION; EXPRESSION;

D O I：

10.1016/j.jff.2021.104397

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study examined if the protective effect of Ellagic acid (EA) against streptozotocin (STZ)-induced diabetic nephropathy (DN) in rats involves activation of Nrf2. Diabetes mellitus was induced by a single i.p dose of STZ (65 mg/kg). The Rats were divided into 5 groups (n = 12/each) and treated for 8 weeks as control, control + EA (100 mg/kg), STZ, STZ + EA (100 mg/kg), and STZ + EA + trigonelline (Nrf2 inhibitor/0.2 mg/kg). EA prevented renal damage, oxidative stress, inflammation, and apoptosis. These effects were associated with reduced activity of NF-?B, upregulated GSH, ?-GCL, and SOD, and increased the nuclear translocation of Nrf2. Besides, EA suppressed the cytoplasmic expression of keap1 and its interaction with Nrf2, increased the phosphorylation of Akt and GS3K?, and reduced the phosphorylation and nuclear accumulation of Fyn. All these alterations were abolished by trigonelline. In conclusion, EA ameliorates DN in rats by antioxidant and anti-inflammatory potentials.

引用

页数：15

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