Diverse Cellular Roles of Autophagy

被引：287

作者：

Morishita, Hideaki ^{[1
]}

Mizushima, Noboru ^{[1
,2
]}

机构：

[1] Univ Tokyo, Grad Sch, Dept Biochem & Mol Biol, Tokyo 1130033, Japan

[2] Univ Tokyo, Fac Med, Tokyo 1130033, Japan

来源：

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 35 | 2019年 / 35卷

基金：

日本学术振兴会;

关键词：

autophagosome; selective autophagy; mitophagy; ER-phagy; nutrient starvation; ENDOPLASMIC-RETICULUM TURNOVER; UBIQUITIN-PROTEASOME SYSTEM; SELECTIVE AUTOPHAGY; PATERNAL MITOCHONDRIA; DAMAGED LYSOSOMES; MEMBRANE-TRAFFICKING; TAGS PEROXISOMES; ULK1; COMPLEX; ATG PROTEINS; DEGRADATION;

D O I：

10.1146/annurev-cellbio-100818-125300

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macroautophagy is an intracellular degradation system that delivers diverse cytoplasmic materials to lysosomes via autophagosomes. Recent advances have enabled identification of several selective autophagy substrates and receptors, greatly expanding our understanding of the cellular functions of autophagy. In this review, we describe the diverse cellular functions of macroautophagy, including its essential contribution to metabolic adaptation and cellular homeostasis. We also discuss emerging findings on the mechanisms and functions of various types of selective autophagy.

引用

页码：453 / 475

页数：23

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