Poly(ADP-ribose) polymerase-1 (PARP-1) longer alleles spanning the promoter region may confer protection to bilateral Meniere's disease

被引：8

作者：

Lopez-Escamez, Jose A. ^{[1
]}

Moreno, Antonia ^{[2
]}

Bernal, Monica ^{[2
]}

Perez-Garrigues, Herminio ^{[3
]}

Santos-Perez, Sofia ^{[4
]}

Soto-Varela, Andres ^{[4
]}

Aran, Ismael ^{[5
]}

Fernandez-Sanfrancisco, Omar ^{[1
]}

Lopez-Nevot, Alicia ^{[6
]}

Lopez-Nevot, Miguel A. ^{[2
]}

机构：

[1] Hosp Poniente Almeria, Otol & Neurotol Grp, Dept Otolaryngol, CTS495, El Ejido 04700, Almeria, Spain

[2] Hosp Univ Virgen Nieves, Dept Immunol, Granada, Spain

[3] Hosp La Fe, Div Otoneurol, Dept Otorhinolaryngol, E-46009 Valencia, Spain

[4] Univ Santiago de Compostela, Div Otoneurol, Dept Otorhinolaryngol, Hosp Clin, Santiago De Compostela, Spain

[5] Complejo Hosp Pontevedra, Dept Otorhinolaryngol, Pontevedra, Spain

[6] Hosp Virgen Nieves, Otol & Neurotol Grp, Dept Otolaryngol, CTS495, Granada, Spain

来源：

ACTA OTO-LARYNGOLOGICA | 2009年 / 129卷 / 11期

关键词：

Sensorineural hearing loss; vertigo; inner ear; transcription factor; neuronal death; endolymphatic hydrops; APOPTOSIS; GENE;

D O I：

10.3109/00016480802684080

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Conclusion: The longer alleles (CA)(17-20) of the promoter region of PARP-1 gene may confer some protection against bilateral Meniere's disease (BMD). Objective: To analyze microsatellite (CA)(n) polymorphisms in the promoter region of PARP-1 gene and seek out risk and protective variants for BMD. Subjects and methods: Eighty patients from two ethnically defined groups with definite BMD, according to the diagnostic scale of the American Academy of Otolaryngology Head and Neck Surgery, were compared with a group of 371 normal controls from the same origin in a prospective multicenter study. We developed a specific amplification protocol to determine the PARP1-promotor CA microsatellite polymorphisms. Results: We found that the longer alleles (CA)(17-20) had a very low frequency in BMD (2/160, 1.3%, OR =7.33 (1.77-30.37, 95% CI), corrected p=0.012), suggesting that it may confer some protection against BMD.

引用

页码：1222 / 1225

页数：4

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