5-HT1A receptors in lithium-induced conditioned taste aversion

被引：14

作者：

Wegener, G ^{[1
]}

Smith, DF ^{[1
]}

Rosenberg, R ^{[1
]}

机构：

[1] AARHUS UNIV,HOSP PSYCHIAT,DEPT BIOL PSYCHIAT,INST BASIC RES PSYCHIAT,DK-8240 RISSKOV,DENMARK

来源：

PSYCHOPHARMACOLOGY | 1997年 / 133卷 / 01期

关键词：

conditioned taste aversion; lithium; serotonin; 5-HT1A receptor; 8-OH-DPAT; pindolol; p-MPPI; PCPA; rat;

D O I：

10.1007/s002130050370

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Experiments were carried out using rats to investigate whether 5-HT1A neural mechanisms are involved in lithium-induced conditioned taste aversion (CTA). We found that the 5-HT1A antagonists p-MPPI and pindolol caused CTA similar to that produced by LICl. The 5-HT1A agonist 8-OH-DPAT counteracted lithium-induced CTA. Pindolol dose-dependently abolished effects of 8-OH-DPAT on LiCl-induced CTA. These findings support the notion that lithium has antagonistic actions on 5-HT1A receptors. Inhibition of 5-HT synthesis by PCPA failed, however, to prevent lithium-induced CTA. Evidently, mechanisms other than those governed solely by 5-HT are also involved in lithium-induced CTA.

引用

页码：51 / 54

页数：4

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