Genes and the environment in neurodegeneration

被引：78
作者：
Coppede, Fabio
Mancuso, Michelangelo
Siciliano, Gabriele
Migliore, Lucia
Murri, Luigi
机构：
[1] Univ Pisa, Dept Neurosci, I-56126 Pisa, Italy
[2] Univ Pisa, Dept Human & Environm Sci, I-56126 Pisa, Italy
来源：
BIOSCIENCE REPORTS | 2006年 / 26卷 / 05期
关键词：
Alzheimer's disease; Parkinson's disease; smyotrophic lateral sclerosis; Huntington's disease; Prion diseases; neurodegeneration; genetics; mitochondria; environmental factors;
D O I：
10.1007/s10540-006-9028-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neurodegenerative diseases are a heterogeneous group of pathologies which includes complex multifactorial diseases, monogenic disorders and disorders for which inherited, sporadic and transmissible forms are known. Factors associated with predisposition and vulnerability to neurodegenerative disorders may be described usefully within the context of gene-environment interplay. There are many identified genetic determinants for neurodegeneration, and it is possible to duplicate many elements of recognized human neurodegenerative disorders in animal models of the disease. However, there are similarly several identifiable environmental influences on outcomes of the genetic defects; and the course of a progressive neurodegenerative disorder can be greatly modified by environmental elements. In this review we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, and prion diseases.) and discuss possible links of gene-environment interplay including, where implicated, mitochondrial genes.
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收藏
页码：341 / 367
页数：27
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