Genes and the environment in neurodegeneration

被引：78
作者：
Coppede, Fabio
Mancuso, Michelangelo
Siciliano, Gabriele
Migliore, Lucia
Murri, Luigi
机构：
[1] Univ Pisa, Dept Neurosci, I-56126 Pisa, Italy
[2] Univ Pisa, Dept Human & Environm Sci, I-56126 Pisa, Italy
来源：
BIOSCIENCE REPORTS | 2006年 / 26卷 / 05期
关键词：
Alzheimer's disease; Parkinson's disease; smyotrophic lateral sclerosis; Huntington's disease; Prion diseases; neurodegeneration; genetics; mitochondria; environmental factors;
D O I：
10.1007/s10540-006-9028-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neurodegenerative diseases are a heterogeneous group of pathologies which includes complex multifactorial diseases, monogenic disorders and disorders for which inherited, sporadic and transmissible forms are known. Factors associated with predisposition and vulnerability to neurodegenerative disorders may be described usefully within the context of gene-environment interplay. There are many identified genetic determinants for neurodegeneration, and it is possible to duplicate many elements of recognized human neurodegenerative disorders in animal models of the disease. However, there are similarly several identifiable environmental influences on outcomes of the genetic defects; and the course of a progressive neurodegenerative disorder can be greatly modified by environmental elements. In this review we highlight some of the major neurodegenerative disorders (Alzheimer's disease, Parkinson's disease, Amyotrophic lateral sclerosis, Huntington's disease, and prion diseases.) and discuss possible links of gene-environment interplay including, where implicated, mitochondrial genes.
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收藏
页码：341 / 367
页数：27
相关论文
共 187 条
[1]   A new familial amyotrophic lateral sclerosis locus on chromosome 16q12.1-16q12.2 [J].
Abalkhail, H ;
Mitchell, J ;
Habgood, J ;
Orrell, R ;
de Belleroche, J .
AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 73 (02) :383-389
[2]   Slow allotypic variants of the NAT2 gene and susceptibility to early-onset Parkinson's disease [J].
Agúndez, JAG ;
Jiménez-Jiménez, FJ ;
Luengo, A ;
Molina, JA ;
Ortí-Pareja, M ;
Vázquez, A ;
Ramos, F ;
Duarte, J ;
Coria, F ;
Ladero, JM ;
Alvarez-Cermeño, JC ;
Benítez, J .
NEUROLOGY, 1998, 51 (06) :1587-1592
[3]   NR2A and NR2B receptor gene variations modify age at onset in Huntington disease [J].
Arning, L ;
Kraus, PH ;
Valentin, S ;
Saft, C ;
Andrich, J ;
Epplen, JT .
NEUROGENETICS, 2005, 6 (01) :25-28
[4]  
Arning Larissa, 2004, BMC Med Genet, V5, P7, DOI 10.1186/1471-2350-5-7
[5]   Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease [J].
Assal, F ;
Alarcón, M ;
Solomon, EC ;
Masterman, D ;
Geschwind, DH ;
Cummings, JL .
ARCHIVES OF NEUROLOGY, 2004, 61 (08) :1249-1253
[6]   Amyloid-β peptide binds with heme to form a peroxidase:: Relationship to the cytopathologies of Alzheimer's disease [J].
Atamna, H ;
Boyle, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (09) :3381-3386
[7]   Mitochondrial DNA polymorphisms as risk factors for Parkinson's disease and Parkinson's disease dementia [J].
Autere, J ;
Moilanen, JS ;
Finnilä, S ;
Soininen, H ;
Mannermaa, A ;
Hartikainen, P ;
Hallikainen, M ;
Majamaa, K .
HUMAN GENETICS, 2004, 115 (01) :29-35
[8]   Neurodegenerative diseases and exposure to pesticides in the elderly [J].
Baldi, I ;
Lebailly, P ;
Mohammed-Brahim, B ;
Letenneur, L ;
Dartigues, JF ;
Brochard, P .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2003, 157 (05) :409-414
[9]   Mitochondria take center stage in aging and neurodegeneration [J].
Beal, MF .
ANNALS OF NEUROLOGY, 2005, 58 (04) :495-505
[10]   Glutathione S-transferase PI *C allelic variant increases susceptibility for late-onset Alzheimer disease:: Association study and relationship with apolipoprotein E ε4 allele [J].
Bernardini, S ;
Bellincampi, L ;
Ballerini, S ;
Federici, G ;
Iori, R ;
Trequattrini, A ;
Ciappi, F ;
Baldinetti, F ;
Bossù, P ;
Caltagirone, C ;
Spalletta, G .
CLINICAL CHEMISTRY, 2005, 51 (06) :944-951
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