WNT Signaling in Disease

被引：190
|
作者：
Ng, Li Fang [1 ]
Kaur, Prameet [1 ]
Bunnag, Nawat [1 ]
Suresh, Jahnavi [1 ]
Sung, Isabelle Chiao Han [1 ]
Tan, Qian Hui [1 ]
Gruber, Jan [1 ]
Tolwinski, Nicholas S. [1 ]
机构：
[1] Yale NUS Coll, Res Labs E6, Div Sci, E6,5 Engn Dr 1,04-02, Singapore 117608, Singapore
来源：
CELLS | 2019年 / 8卷 / 08期
关键词：
WNT; cancer; metabolic syndrome; Alzheimer's disease; WNT/BETA-CATENIN PATHWAY; RECEPTOR-RELATED PROTEIN-5; SMALL-MOLECULE INHIBITOR; FAMILIAL ADENOMATOUS POLYPOSIS; GLYCOGEN-SYNTHASE KINASE-3; FRAGILE-X-SYNDROME; CANCER STEM-CELLS; BETA-CATENIN; MATRIX METALLOPROTEINASE-7; OXIDATIVE STRESS;
D O I：
10.3390/cells8080826
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide range of pathologies in humans. Here, we discuss the WNT pathway and its role in human disease and some of the advances in WNT-related treatments.
引用
收藏
页数：32
相关论文
共 50 条
  • [31] Wnt/β-Catenin Signaling and Disease
    Clevers, Hans
    Nusse, Roel
    CELL, 2012, 149 (06) : 1192 - 1205
  • [32] The Wnt signaling pathway in cancer
    Duchartre, Yann
    Kim, Yong-Mi
    Kahn, Michael
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2016, 99 : 141 - 149
  • [33] Wnt Signaling in the Tumor Microenvironment
    Ruan, Yongsheng
    Ogana, Heather
    Gang, Eunji
    Kim, Hye Na
    Kim, Yong-Mi
    TUMOR MICROENVIRONMENT: SIGNALING PATHWAYS, PT B, 2021, 1270 : 107 - 121
  • [34] Wnt signaling in cervical cancer?
    Yang, Min
    Wang, Min
    Li, Xianping
    Xie, Yixin
    Xia, Xiaomeng
    Tian, Jingjing
    Zhang, Kan
    Tang, Aiguo
    JOURNAL OF CANCER, 2018, 9 (07): : 1277 - 1286
  • [35] Dishevelled: The hub of Wnt signaling
    Gao, Chan
    Chen, Ye-Guang
    CELLULAR SIGNALLING, 2010, 22 (05) : 717 - 727
  • [36] Wnt signaling in development and disease
    Freese, Jennifer L.
    Pino, Darya
    Pleasure, Samuel J.
    NEUROBIOLOGY OF DISEASE, 2010, 38 (02) : 148 - 153
  • [37] Wnt signaling and tumors (Review)
    Wang, Huaishi
    Zhang, Lihai
    Hu, Chao
    Li, Hui
    Jiang, Mingyan
    MOLECULAR AND CLINICAL ONCOLOGY, 2024, 21 (01)
  • [38] Wnt signaling in cardiovascular physiology
    Marinou, K.
    Christodoulides, C.
    Antoniades, C.
    Koutsilieris, M.
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2012, 23 (12) : 628 - 636
  • [39] Regulation of Wnt Signaling Pathways at the Plasma Membrane and Their Misregulation in Cancer
    Azbazdar, Yagmur
    Karabicici, Mustafa
    Erdal, Esra
    Ozhan, Gunes
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 9
  • [40] Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms
    Novellasdemunt, Laura
    Antas, Pedro
    Li, Vivian S. W.
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2015, 309 (08): : C511 - C521
12345