WNT Signaling in Disease

被引：190
|
作者：
Ng, Li Fang [1 ]
Kaur, Prameet [1 ]
Bunnag, Nawat [1 ]
Suresh, Jahnavi [1 ]
Sung, Isabelle Chiao Han [1 ]
Tan, Qian Hui [1 ]
Gruber, Jan [1 ]
Tolwinski, Nicholas S. [1 ]
机构：
[1] Yale NUS Coll, Res Labs E6, Div Sci, E6,5 Engn Dr 1,04-02, Singapore 117608, Singapore
来源：
CELLS | 2019年 / 8卷 / 08期
关键词：
WNT; cancer; metabolic syndrome; Alzheimer's disease; WNT/BETA-CATENIN PATHWAY; RECEPTOR-RELATED PROTEIN-5; SMALL-MOLECULE INHIBITOR; FAMILIAL ADENOMATOUS POLYPOSIS; GLYCOGEN-SYNTHASE KINASE-3; FRAGILE-X-SYNDROME; CANCER STEM-CELLS; BETA-CATENIN; MATRIX METALLOPROTEINASE-7; OXIDATIVE STRESS;
D O I：
10.3390/cells8080826
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide range of pathologies in humans. Here, we discuss the WNT pathway and its role in human disease and some of the advances in WNT-related treatments.
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页数：32
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