Association of eNOS and Cav-1 gene polymorphisms with susceptibility risk of large artery atherosclerotic stroke

被引:20
|
作者
Shyu, Hann-Yeh [1 ,2 ]
Chen, Ming-Hua [1 ,3 ]
Hsieh, Yi-Hsien [4 ]
Shieh, Jia-Ching [5 ]
Yen, Ling-Rong [1 ]
Wang, Hsiao-Wei [4 ,6 ]
Cheng, Chun-Wen [4 ,6 ]
机构
[1] Armed Forces Taoyuan Gen Hosp, Dept Internal Med, Neurol Sect, Taoyuan, Taiwan
[2] Natl Def Med Ctr, Inst Biol & Anat, Taipei, Taiwan
[3] Natl Def Med Ctr, Triservice Gen Hosp, Dept Neurol, Taipei, Taiwan
[4] Chung Shan Med Univ, Inst Biochem Microbiol & Immunol, Taichung, Taiwan
[5] Chung Shan Med Univ, Dept Biomed Sci, Taichung, Taiwan
[6] Chung Shan Med Univ Hosp, Clin Lab, Taichung, Taiwan
来源
PLOS ONE | 2017年 / 12卷 / 03期
关键词
NITRIC-OXIDE SYNTHASE; CARDIOVASCULAR-DISEASES; CAVEOLIN-1; GENE; ISCHEMIC-STROKE; EXPRESSION; GLU298ASP; VARIANTS; SUBTYPE;
D O I
10.1371/journal.pone.0174110
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Endothelial nitric oxide synthase (eNOS) is localized in caveole and has important effects on caveolar coordination through its interaction with caveolin-1 (Cav-1), which supports normal functioning of vascular endothelial cells. However, the relationship between genotypic polymorphisms of e-NOS and Cav-1 genes and ischemic stroke (IS) remains lesser reported. This hospital-based case-control study aimed to determine the genetic polymorphisms of the eNOS (GIu298Asp) and Cav-1 (G14713A and T29107A) genes in association with susceptibility risk in patients who had suffered from a large artery atherosclerotic (LAA) stroke. Genotyping determination for these variant alleles was performed using the TaqMan assay. The distributions of observed allelic and genotypic frequencies for the polymorphisms were in Hardy-Weinberg equilibrium in healthy controls. The risk for an LAA stroke in the Asp298 variant was 1.72 (95% CI = 1.09-2.75) versus G1u298 of the eNOS. In the GA/AA (rs3807987) variant, it was 1.79 (95% CI = 1.16-2.74) versus GG and in TA/AA (rs7804372) was 1.61 (95% CI = 1.06-2.43) versus TTof the Cav-1, respectively. A tendency toward an increased LAA stroke risk was significant in carriers with the eNOS GIu298Asp variant in conjunction with the G14713 A and T29107A polymorphisms of the Cav-1 (aOR = 2.03, P- "trend = 0.002). A synergistic effect between eNOS and Cav-1 polymorphisms on IS risk elevation was significantly influenced by alcohol drinking, heavy cigarette smoking (P "trend<0.01), and hypercholesterolemia (P "trend < 0.001). In conclusion, genotypic polymorphisms of the eNOS GIu298Asp and Cav-1 14713A/29107A polymorphisms are associated with the elevated risk of LAA stroke among Han Chinese in Taiwan.
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页数:12
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