Synthesis of some new pyrazolyl-thiazolidinone derivatives starting from 1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazole-4-carboxaldehyde

被引：2

作者：

Khalifa, N. M. ^{[1
,2
]}

Nossier, E. S. ^{[3
]}

Al-Omar, M. A. ^{[1
]}

机构：

[1] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, Riyadh 11451, Saudi Arabia

[2] Natl Res Ctr, Pharmaceut & Drug Ind Div, Dept Therapeut Chem, Cairo 12622, Egypt

[3] Al Azhar Univ, Fac Pharm Girls, Dept Pharmaceut Chem, Cairo 11754, Egypt

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2017年 / 87卷 / 04期

关键词：

thiazolidin-4-ones; 1,3-diaryl pyrazole derivatives; synthesis; DOCKING; DESIGN;

D O I：

10.1134/S1070363217040338

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel synthetic approach to (E)-1-{[1-(3-chlorophenyl)-3-[(4-methoxyphenyl-1H-pyrazol-4-yl)- methylene]hydrazono}-3-phenylthiazolidin-4-one starting from the key intermediate thiosemicarbazone derivative is presented. The latter compound reacted with some aromatic and heterocyclic aldehydes to give (1-{[1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazol-4-yl]methylene}hydrazono)-5-(substituted benzylidene)-3-phenylthiazolidin-4-one derivatives.

引用

页码：868 / 872

页数：5

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