Garlic for Cardiovascular Disease: Prevention or Treatment?

被引:34
作者
Alali, Feras Q. [1 ]
El-Elimatb, Tamam [2 ]
Khalid, Lila [2 ]
Hudaib, Reema [2 ]
Al-Shehabi, Tuqa Saleh [3 ]
Eid, Ali H. [4 ]
机构
[1] Qatar Univ, Fac Pharm, POB 2713, Doha, Qatar
[2] Jordan Univ Sci & Technol, Fac Pharm, Dept Med Chem & Pharmacognosy, Irbid 22110, Jordan
[3] Qatar Univ, Dept Hlth Sci, Doha, Qatar
[4] Amer Univ Beirut, Fac Med, Dept Pharmacol & Toxicol, POB 11-0236, Beirut, Lebanon
关键词
Cardiovascular disease; atherosclerosis; hypertension; thrombosis; hyperlipidemia; garlic; Allium sativum; herbal medicine; DIASTOLIC BLOOD-PRESSURE; HYDROGEN-SULFIDE; ALLIUM-SATIVUM; S-ALLYLCYSTEINE; DOUBLE-BLIND; DRUG-INTERACTIONS; POWDER TABLETS; SERUM-LIPIDS; RISK-FACTORS; IN-VITRO;
D O I
10.2174/1381612822666161010124530
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cardiovascular disease (CVD) is the leading cause of global mortality with a substantial economic impact. The annual deaths are expected to increase in the next decade. An array of dietary supplements is being used by people worldwide to ameliorate cardiovascular risk factors. Garlic (Allium sativum L.), a top-selling herbal dietary supplement, is renowned for its wide range beneficial effects, particularly in the treatment and prevention of CVD. This review aims to present a thorough discussion of the available evidence-based data which support the use of garlic in the treatment or prevention of cardiovascular diseases, including atherosclerosis, hypertension, and hyperlipidemia. The molecular mechanisms underlying these effects are dissected as well. This review supports the notion that garlic has the potential to treat mild hypertension, to decrease hypercholes-terolemia, and to prevent atherosclerosis. More clinical studies are essential to unequivocally understand the mechanisms underlying treatment or prevention of these cardiovascular conditions.
引用
收藏
页码:1028 / 1041
页数:14
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