Cardiovascular disease (CVD) is the leading cause of global mortality with a substantial economic impact. The annual deaths are expected to increase in the next decade. An array of dietary supplements is being used by people worldwide to ameliorate cardiovascular risk factors. Garlic (Allium sativum L.), a top-selling herbal dietary supplement, is renowned for its wide range beneficial effects, particularly in the treatment and prevention of CVD. This review aims to present a thorough discussion of the available evidence-based data which support the use of garlic in the treatment or prevention of cardiovascular diseases, including atherosclerosis, hypertension, and hyperlipidemia. The molecular mechanisms underlying these effects are dissected as well. This review supports the notion that garlic has the potential to treat mild hypertension, to decrease hypercholes-terolemia, and to prevent atherosclerosis. More clinical studies are essential to unequivocally understand the mechanisms underlying treatment or prevention of these cardiovascular conditions.
机构:
Mil Med Inst, Dept Rehabil, Warsaw, Poland
Jan Kochanowski Univ Humanities & Sci, Div Phys Med, Kielce, PolandMil Med Inst, Dept Rehabil, Warsaw, Poland
Kulinski, Wlodzislaw
Lebioda, Patrycja
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Med Univ Lodz, Cent Teaching Hosp, Dept Cardiol, Lodz, PolandMil Med Inst, Dept Rehabil, Warsaw, Poland
机构:
Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, EnglandKings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England
Wood, Eleanor
Hein, Sabine
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Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England
Univ Reading, Sch Psychol & Clin Language Sci, Reading, Berks, EnglandKings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England
Hein, Sabine
Heiss, Christian
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Univ Surrey, Fac Hlth & Med Sci, Guildford, Surrey, England
Surrey & Sussex Healthcare NHS Trust, Redhill, Surrey, EnglandKings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England
Heiss, Christian
Williams, Claire
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Univ Reading, Sch Psychol & Clin Language Sci, Reading, Berks, EnglandKings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England
Williams, Claire
Rodriguez-Mateos, Ana
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Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, EnglandKings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England
机构:
Queen Mary Univ London, Barts & London Sch Med, Wolfson Inst Prevent Med, London EC1M 6BQ, EnglandQueen Mary Univ London, Barts & London Sch Med, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Wald, David S.
Wald, Nicholas J.
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Queen Mary Univ London, Barts & London Sch Med, Wolfson Inst Prevent Med, London EC1M 6BQ, EnglandQueen Mary Univ London, Barts & London Sch Med, Wolfson Inst Prevent Med, London EC1M 6BQ, England
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Yale Univ, Phys Assistant Online Program, Sch Med, POB 208004, New Haven, CT 06520 USAYale Univ, Phys Assistant Online Program, Sch Med, POB 208004, New Haven, CT 06520 USA
Kilstrom, Jonathan
Wildermuth, Anne
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机构:
George Washington Univ, Dept Phys Assistant Studies, Sch Med & Hlth Sci, 2300 Eye St Northwest,Suite 226, Washington, DC 20052 USAYale Univ, Phys Assistant Online Program, Sch Med, POB 208004, New Haven, CT 06520 USA
机构:
Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Sect Cardiovasc Res, Houston, TX 77030 USAMinneapolis Heart Inst, Minneapolis, MN USA
机构:
Calif State Univ Fresno, Div Cardiol, Dept Med, Vet Affairs Cent Calif Hlth Care Syst,Fresno Prog, Fresno, CA 93703 USAFortis Escorts Hosp, Dept Med, Jaipur 302017, Rajasthan, India
机构:
Mil Med Inst, Dept Rehabil, Warsaw, Poland
Jan Kochanowski Univ Humanities & Sci, Div Phys Med, Kielce, PolandMil Med Inst, Dept Rehabil, Warsaw, Poland
Kulinski, Wlodzislaw
Lebioda, Patrycja
论文数: 0引用数: 0
h-index: 0
机构:
Med Univ Lodz, Cent Teaching Hosp, Dept Cardiol, Lodz, PolandMil Med Inst, Dept Rehabil, Warsaw, Poland
机构:
Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, EnglandKings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England
Wood, Eleanor
Hein, Sabine
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England
Univ Reading, Sch Psychol & Clin Language Sci, Reading, Berks, EnglandKings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England
Hein, Sabine
Heiss, Christian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Surrey, Fac Hlth & Med Sci, Guildford, Surrey, England
Surrey & Sussex Healthcare NHS Trust, Redhill, Surrey, EnglandKings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England
Heiss, Christian
Williams, Claire
论文数: 0引用数: 0
h-index: 0
机构:
Univ Reading, Sch Psychol & Clin Language Sci, Reading, Berks, EnglandKings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England
Williams, Claire
Rodriguez-Mateos, Ana
论文数: 0引用数: 0
h-index: 0
机构:
Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, EnglandKings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England
机构:
Queen Mary Univ London, Barts & London Sch Med, Wolfson Inst Prevent Med, London EC1M 6BQ, EnglandQueen Mary Univ London, Barts & London Sch Med, Wolfson Inst Prevent Med, London EC1M 6BQ, England
Wald, David S.
Wald, Nicholas J.
论文数: 0引用数: 0
h-index: 0
机构:
Queen Mary Univ London, Barts & London Sch Med, Wolfson Inst Prevent Med, London EC1M 6BQ, EnglandQueen Mary Univ London, Barts & London Sch Med, Wolfson Inst Prevent Med, London EC1M 6BQ, England
机构:
Yale Univ, Phys Assistant Online Program, Sch Med, POB 208004, New Haven, CT 06520 USAYale Univ, Phys Assistant Online Program, Sch Med, POB 208004, New Haven, CT 06520 USA
Kilstrom, Jonathan
Wildermuth, Anne
论文数: 0引用数: 0
h-index: 0
机构:
George Washington Univ, Dept Phys Assistant Studies, Sch Med & Hlth Sci, 2300 Eye St Northwest,Suite 226, Washington, DC 20052 USAYale Univ, Phys Assistant Online Program, Sch Med, POB 208004, New Haven, CT 06520 USA
机构:
Baylor Coll Med, Michael E DeBakey Vet Affairs Med Ctr, Houston, TX 77030 USA
Baylor Coll Med, Sect Cardiovasc Res, Houston, TX 77030 USAMinneapolis Heart Inst, Minneapolis, MN USA
机构:
Calif State Univ Fresno, Div Cardiol, Dept Med, Vet Affairs Cent Calif Hlth Care Syst,Fresno Prog, Fresno, CA 93703 USAFortis Escorts Hosp, Dept Med, Jaipur 302017, Rajasthan, India