Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications

被引：127

作者：

Nelson, Bryce J. B. ^{[1
]}

Andersson, Jan D. ^{[1
,2
]}

Wuest, Frank ^{[1
]}

机构：

[1] Univ Alberta, Dept Oncol, 11560 Univ Ave, Edmonton, AB T6G 1Z2, Canada

[2] Alberta Hlth Serv, Edmonton Radiopharmaceut Ctr, 11560 Univ Ave, Edmonton, AB T6G 1Z2, Canada

来源：

PHARMACEUTICS | 2021年 / 13卷 / 01期

关键词：

targeted alpha therapy; alpha particle therapy; targeted radionuclide therapy; theranostics; actinium-225; bismuth-213; astatine-211; radium-223; thorium-227; terbium-149;

D O I：

10.3390/pharmaceutics13010049

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This review outlines the accomplishments and potential developments of targeted alpha (alpha) particle therapy (TAT). It discusses the therapeutic advantages of the short and highly ionizing path of alpha-particle emissions; the ability of TAT to complement and provide superior efficacy over existing forms of radiotherapy; the physical decay properties and radiochemistry of common alpha-emitters, including Ac-225, Bi-213, Ra-224, Pb-212, Th-227, Ra-223, At-211, and Tb-149; the production techniques and proper handling of alpha-emitters in a radiopharmacy; recent preclinical developments; ongoing and completed clinical trials; and an outlook on the future of TAT.

引用

页码：1 / 28

页数：26

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