New sesquiterpene and thiophene derivatives from Artemisia rupestris

被引：8

作者：

Zhang, Chen ^{[1
]}

Liu, Bing-Yu ^{[1
]}

Zeng, Ke-Wu ^{[1
]}

Guo, Xiao-Yu ^{[1
]}

Jiang, Yong ^{[1
]}

Tu, Peng-Fei ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2015年 / 17卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Compositae; Artemisia rupestris; sesquiterpene; thiophene derivatives; NO inhibition;

D O I：

10.1080/10286020.2015.1118623

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new sesquiterpene, rupestrisin A (1), and three new thiophene derivatives, rupestrienes A-C (2-4), were isolated from Artemisia rupestris. Their structures were determined by analyses of MS and NMR spectroscopic data, and the absolute configuration of 1 was established by calculated ECD spectra using time-dependent density functional theory. In in vitro bioassays, compounds 1-4 showed inhibitory effects on LPS-stimulated NO production in BV-2 microglial cells with IC50 values of 24.3, 20.3, 8.5, and 5.3M, respectively. [GRAPHICS] .

引用

页码：1129 / 1136

页数：8

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