TRPV1 activation inhibits phenotypic switching and oxidative stress in vascular smooth muscle cells by upregulating PPARa

被引：17

作者：

Zhou, Yi ^{[1
]}

Wang, Xueli ^{[1
]}

Guo, Lu ^{[2
]}

Chen, Lizhao ^{[3
]}

Zhang, Mingjie ^{[4
]}

Chen, Xue ^{[5
]}

Li, Jingcheng ^{[2
]}

Zhang, Lili ^{[2
]}

机构：

[1] 980 Hosp PLA Joint Logist Support Forces, Dept Neurol, 398 ZhongShan Xi Rd, Shijiazhuang, Hebei, Peoples R China

[2] Army Med Univ, Dept Neurol, Daping Hosp, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China

[3] Army Med Univ, Daping Hosp, Dept Neurosurg, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China

[4] Gen Hosp Western Theater Command, Dept Neurol, 270 Tianhuan Rd,Rongdu Ave, Chengdu, Sichuan, Peoples R China

[5] Yaan Peoples Hosp, Dept Neurol, 358 Chenghou Rd, Yaan City, Sichuan, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2021年 / 545卷

基金：

中国国家自然科学基金;

关键词：

Phenotypic switching; Oxidative stress; Transient receptor potential vanilloid 1; Peroxisome proliferator activated receptor a; LIPID-ACCUMULATION; OXIDIZED LDL; RECEPTOR; CHANNELS; PROLIFERATION; INFLAMMATION; RESISTANCE; GROWTH; ONSET;

D O I：

10.1016/j.bbrc.2021.01.072

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The proliferation and migration of vascular smooth muscle cells (VSMCs) is one of main reasons of vascular remodeling and is the pathogenesis of atherosclerosis and other vascular diseases. Transient receptor potential vanilloid 1 (TRPV1) is the specific receptor of capsaicin. TRPV1 has been previously reported to inhibit proliferation, migration and phenotypic switching, but the regulatory mechanisms and relevant signalling pathways are not clear. The aim of this study was to investigate the effects of capsaicin-activated TRPV1 on VSMC phenotypic switching. In this study, oxidized low density lipoprotein (ox-LDL) was used to induce the proliferation and migration of VSMCs. Our data showed that the VSMC proliferation induced by ox-LDL was dependent on the concentration of ox-LDL. Nevertheless, the data showed that capsaicin activated TRPV1 significantly decreased ox-LDL-induced superoxide anion generation. Phenotypic switching of VSMCs was inhibited by the activation of TRPV1. Furthermore, capsaicin decreased ox-LDL-induced superoxide anion generation by activating peroxisome proliferator activated receptor a (PPARa). TRPV1 inhibited VSMC phenotypic switching via upregulated expression of PPARa. It may be considered a useful target for the treatment of vascular remodeling. (c) 2021 Elsevier Inc. All rights reserved.

引用

页码：157 / 163

页数：7

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