Effects of rikkunshito on quality of life in patients with gastroesophageal reflux disease refractory to proton pump inhibitor therapy

被引：8

作者：

Kawai, Takashi ^{[1
]}

Hirayama, Yoji ^{[2
]}

Oguchi, Aiko ^{[3
]}

Ishii, Fumi ^{[4
]}

Matushita, Masanao ^{[5
]}

Kitayama, Naoya ^{[6
]}

Morishita, Shinji ^{[6
]}

Hiratsuka, Noboru ^{[7
]}

Ohata, Ken ^{[8
]}

Konishi, Hiroyuki ^{[9
]}

Kishino, Maiko ^{[9
]}

Nakamura, Shinichi ^{[9
]}

机构：

[1] Tokyo Med Univ, Gastroenterol Endoscopy, Shinjuku Ku, 6-7-1 Nishishinjuku, Tokyo 1600023, Japan

[2] Tokyo Med Univ Hosp, Dept Gen Med & Primary Care, Shinjuku Ku, 6-7-1 Nishishinjuku, Tokyo 1600023, Japan

[3] Shinjuku NS Bldg Clin, Shinjuku Ku, 2-4-1 Nishishinjuku, Tokyo 1630820, Japan

[4] Shinjuku Mitsui Bldg Clin, Shinjuku Ku, 2-4-1 Nishishinjuku, Tokyo 1830410, Japan

[5] Int Catholic Hosp, Dept Internal Med, Shinjuku Ku, 2-5-1 Nakaochiai, Tokyo 1618521, Japan

[6] Tokyo Shinjuku Med Ctr, Dept Gastroenterol, Shinjuku Ku, 5-1 Tsukudo Cho, Tokyo 1620821, Japan

[7] Hiratsuka Gastroenterol Hosp Shinjuku Ctr Clin, Shinjuku Ku, 1-25-1 Nishishinjuku, Tokyo 1630690, Japan

[8] NTT Med Ctr Tokyo, Dept Gastroenterol, Shinagawa Ku, 5-9-22 Higashi Gotanda, Tokyo 1418625, Japan

[9] Tokyo Womens Med Univ Hosp, Dept Gastroenterol, Shinjuku Ku, 8-1 Kawada Cho, Tokyo 1628666, Japan

来源：

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2017年 / 60卷 / 02期

关键词：

quality of life; gastroesophageal reflux disease; rikkunshito; proton pump inhibitor; CISPLATIN-INDUCED ANOREXIA; GASTROINTESTINAL SYMPTOMS; ESOPHAGITIS; SECRETION; MEDICINE; JAPAN; RATS;

D O I：

10.3164/jcbn.16-77

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

We investigated the effects of rikkunshito, in combination with a proton pump inhibitor, on symptoms and quality of life in patients with proton pump inhibitor-refractory gastroesophageal reflux disease. The subjects were 47 patients with gastroesophageal reflux disease with residual symptoms such as heartburn following 8 weeks of proton pump inhibitor therapy. We administered these subjects rikkunshito in combination with a proton pump inhibitor for 6-8 weeks. We scored their symptoms of heartburn, fullness, abdominal discomfort, and abdominal pain, and surveyed their quality of life using the Reflux Esophagitis Symptom Questionnaire, comprising questions concerning daily activities, meals (changes in amount and favorite foods), and sleep (getting to sleep and early morning waking). Improvement was seen in all symptoms, and quality of life scores for meals and sleep also improved. These results indicate that combination therapy with rikkunshito and a proton pump inhibitor improves quality of life related to eating and sleep in patients with patients with proton pump inhibitor-refractory gastroesophageal reflux disease.

引用

页码：143 / 145

页数：3

共 26 条

[1] Correlation between symptomatic improvement and quality of life in patients with reflux and dyspeptic symptoms
Arihiro, Seiji
Kato, Tomohiro
Ito, Kyoko
Saruta, Masayuki
Nikami, Toshiki
Suzuki, Takeshi
Tajiri, Hisao
[J]. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 2012, 50 (03) : 205 - 210
[2] Comparative study of characteristics and disease management between subjects with frequent and occasional gastro-oesophageal reflux symptoms
Bretagne, JF
Honnorat, C
Richard-Molard, B
Caekaert, A
Barthélemys, P
[J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2006, 23 (05) : 607 - 616
[3] Reversibility of GERD ultrastructural alterations and relief of symptoms after omeprazole treatment
Calabrese, C
Bortolotti, M
Fabbri, A
Areni, A
Cenacchi, G
Scialpi, C
Miglioli, M
Di Febo, G
[J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2005, 100 (03) : 537 - 542
[4] The role of esophageal pH monitoring in symptomatic patients on PPI therapy
Charbel, S
Khandwala, F
Vaezi, MF
[J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2005, 100 (02) : 283 - 289
[5] Fass R, 2005, ALIMENT PHARM THER, V22, P79, DOI 10.1111/j.1365-2036.2005.02531.x
[6] Epidemiology and clinical characteristics of GERD in the Japanese population
Fujiwara, Yasuhiro
Arakawa, Tetsuo
[J]. JOURNAL OF GASTROENTEROLOGY, 2009, 44 (06) : 518 - 534
[7] Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole
Furuta, T
Shirai, N
Watanabe, F
Honda, S
Takeuchi, K
Iida, T
Sato, Y
Kajimura, M
Futami, H
Takayanagi, S
Yamada, M
Ohashi, K
Ishizaki, T
Hanai, H
[J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2002, 72 (04) : 453 - 460
[8] Hongo M, 2008, PROG MED, V28, P2219
[9] Psychometric validation of the Japanese translation of the Quality of Life in Reflux and Dyspepsia questionnaire in patients with heartburn
Hongo, Michio
Kinoshita, Yoshikazu
Shimozuma, Kojiro
Kumagai, Yuji
Sawada, Mitsutaka
Nii, Masahiro
[J]. JOURNAL OF GASTROENTEROLOGY, 2007, 42 (10) : 807 - 815
[10] Japanese Society of Gastroenterology, 2009, THER GUID GASTR REFL

← 1 2 3 →