Solubility of sulphadiazine in some {Carbitol® (1) + water (2)} mixtures: determination, correlation, and preferential solvation

被引:17
作者
Osorio, Irmis P. [1 ]
Martinez, Fleming [1 ]
Pena, Maria A. [2 ]
Jouyban, Abolghasem [3 ,4 ,5 ]
Acree Jr, William E. [6 ]
机构
[1] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fisicoquim,Sede Bogota, Bogota, Colombia
[2] Univ Alcala, Fac Farm, Dept Ciencias Biomed, Alcala De Henares, Spain
[3] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz 51664, Iran
[4] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran
[5] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Tehran, Iran
[6] Univ North Texas, Dept Chem, Denton, TX 76203 USA
关键词
Sulphadiazine; Carbitol® solubility; Jouyban-Acree model; preferential solvation; PLUS WATER MIXTURES; ENTHALPY-ENTROPY COMPENSATION; PREFERENTIAL SOLVATION; SOLUTION THERMODYNAMICS; MATHEMATICAL REPRESENTATION; PREDICT SOLUBILITY; SOLVENT MIXTURES; DRUGS; SULFAMETHAZINE; TEMPERATURES;
D O I
10.1080/00319104.2020.1858420
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The mole fraction solubility of sulphadiazine (SD) in {Carbitol (R) (1) + water (2)} binary solvent mixtures at different temperatures from (278.15 to 313.15) K was determined. Solubility values were correlated with the combined nearly ideal binary solvent/Redlich-Kister, modified Wilson and Jouyban-Acree models. Preferential solvation parameters of SD by Carbitol (R) (delta x (1,3)) were derived from their thermodynamic solution properties using the inverse Kirkwood-Buff integrals method. delta x (1,3) values are negative in water-rich mixtures but positive in Carbitol (R) mole fractions higher than 0.12. In the former case is conjecturable that hydrophobic hydration around non-polar groups of SD plays a relevant role in drug solvation.
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页码:890 / 906
页数:17
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