Fetal Malformations Associated with the Use of Methylphenobarbital and Carbamazepine during Pregnancy

被引：2
作者：
Aksamija, Alenka [1 ]
Habek, Dubravko [1 ]
Stanojevic, Milan [1 ]
Ujevic, Boris [1 ]
机构：
[1] Univ Zagreb, Sveti Duh Gen Hosp, Univ Dept Obstet & Gynecol, Clin Gynecol & Obstet, HR-10000 Zagreb, Croatia
来源：
FETAL DIAGNOSIS AND THERAPY | 2009年 / 25卷 / 01期
关键词：
Epilepsy; Pregnancy; Anticonvulsant drugs; Congenital malformations; ANTIEPILEPTIC DRUGS; IN-UTERO; EPILEPSY; WOMEN; EXPOSURE; CHILDREN; OXCARBAZEPINE; ANTICONVULSANTS; TERATOGENICITY; MANAGEMENT;
D O I：
10.1159/000201945
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The use of antiepileptic drugs (AEDs) during pregnancy has been associated with an increased risk of major and minor fetal malformations. This paper describes 2 infants with malformations born to epileptic mothers who used AEDs throughout pregnancy. In the first case, the AED used for seizure control was methylphenobarbital, while in the second case the patient had been prescribed carbamazepine. We noted major and minor congenital malformations in both infants exposed in utero to these anticonvulsant drugs. Pregnant women still experience poor obstetrical care because they report to tertiary centers at the end of their pregnancy or when in labor, making it difficult to provide proper medical care for both the infant and the mother. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码：79 / 82
页数：4
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