Fetal Malformations Associated with the Use of Methylphenobarbital and Carbamazepine during Pregnancy

被引：3

作者：

Aksamija, Alenka ^{[1
]}

Habek, Dubravko ^{[1
]}

Stanojevic, Milan ^{[1
]}

Ujevic, Boris ^{[1
]}

机构：

[1] Univ Zagreb, Sveti Duh Gen Hosp, Univ Dept Obstet & Gynecol, Clin Gynecol & Obstet, HR-10000 Zagreb, Croatia

来源：

FETAL DIAGNOSIS AND THERAPY | 2009年 / 25卷 / 01期

关键词：

Epilepsy; Pregnancy; Anticonvulsant drugs; Congenital malformations; ANTIEPILEPTIC DRUGS; IN-UTERO; EPILEPSY; WOMEN; EXPOSURE; CHILDREN; OXCARBAZEPINE; ANTICONVULSANTS; TERATOGENICITY; MANAGEMENT;

D O I：

10.1159/000201945

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The use of antiepileptic drugs (AEDs) during pregnancy has been associated with an increased risk of major and minor fetal malformations. This paper describes 2 infants with malformations born to epileptic mothers who used AEDs throughout pregnancy. In the first case, the AED used for seizure control was methylphenobarbital, while in the second case the patient had been prescribed carbamazepine. We noted major and minor congenital malformations in both infants exposed in utero to these anticonvulsant drugs. Pregnant women still experience poor obstetrical care because they report to tertiary centers at the end of their pregnancy or when in labor, making it difficult to provide proper medical care for both the infant and the mother. Copyright (C) 2009 S. Karger AG, Basel

引用

收藏

页码：79 / 82

页数：4

相关论文

共 54 条

[1] The longer term outcome of children born to mothers with epilepsy [J].

Adab, N ;

Kini, U ;

Vinten, J ;

Ayres, J ;

Baker, G ;

Clayton-Smith, J ;

Coyle, H ;

Fryer, A ;

Gorry, J ;

Gregg, J ;

Mawer, G ;

Nicolaides, P ;

Pickering, L ;

Tunnicliffe, L ;

Chadwick, DW .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2004, 75 (11) :1575-1583

[2] Antieplileptic drug use and birth rate in patients with epilepsy -: a population-based cohort study in Finland [J].

Artama, Miia ;

Isojarvi, J. I. T. ;

Auvinen, A. .

HUMAN REPRODUCTION, 2006, 21 (09) :2290-2295

[3] The frequency of neonatal morbidity after exposure to antiepileptic drugs in utero [J].

Burja, Silva ;

Rakovec-Felser, Zlatka ;

Treiber, Milena ;

Hajdinjak, Dusanka ;

Gajsek-Marchetti, Marijana .

WIENER KLINISCHE WOCHENSCHRIFT, 2006, 118 (9-10) :12-16

[4] Oxcarbazepine concentrations during pregnancy: A retrospective study in patients with epilepsy [J].

Christensen, Jakob ;

Sabers, Anne ;

Sidenius, Per .

NEUROLOGY, 2006, 67 (08) :1497-1499

[5] Best practice guidelines for the management of women with epilepsy [J].

Crawford, P .

EPILEPSIA, 2005, 46 :117-124

[6] Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth [J].

Dean, JCS ;

Hailey, H ;

Moore, SJ ;

Lloyd, DJ ;

Turnpenny, PD ;

Little, J .

JOURNAL OF MEDICAL GENETICS, 2002, 39 (04) :251-259

[7] Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies [J].

Diav-Citrin, O ;

Shechtman, S ;

Arnon, J ;

Ornoy, A .

NEUROLOGY, 2001, 57 (02) :321-324

[8] Assessing epidemiological evidence for the teratogenic effects of anticonvulsant medications [J].

Dolk, H ;

McElhatton, P .

JOURNAL OF MEDICAL GENETICS, 2002, 39 (04) :243-245

[9] Population based, prospective study of the care of women with epilepsy in pregnancy [J].

Fairgrieve, SD ;

Jackson, M ;

Jonas, P ;

Walshaw, D ;

White, K ;

Montgomery, TL ;

Burn, J ;

Lynch, SA .

BRITISH MEDICAL JOURNAL, 2000, 321 (7262) :674-675

[10] Drug treatment of epilepsy [J].

Feely, M .

BRITISH MEDICAL JOURNAL, 1999, 318 (7176) :106-109

← 1 2 3 4 5 6 →