Cellular plasticity of the pancreas

被引：9
|
作者：
Baeyens, Luc [1 ]
Bouwens, Luc [1 ]
机构：
[1] Vrije Univ Brussel, Cell Differentiat Unit, Diabet Res Ctr, B-1090 Brussels, Belgium
来源：
BIOLOGICAL CHEMISTRY | 2009年 / 390卷 / 10期
关键词：
beta-cells; cell reprogramming; metaplasia; pancreas; plasticity; transdifferentiation; INSULIN-SECRETING CELLS; EPIDERMAL-GROWTH-FACTOR; BETA-CELLS; ACINAR-CELLS; ADULT-RAT; PROGENITOR CELLS; MOLECULAR-BASIS; DUCT CELLS; IN-VIVO; DIFFERENTIATION;
D O I：
10.1515/BC.2009.117
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell replacement therapy holds promises for treatment of patients suffering from diabetes mellitus. When determining the appropriate strategies to amplify the amount of transplantable beta-cells, sufficient knowledge of the developmental programs regulating beta-cell differentiation is crucial. Here, we describe the plasticity of the different pancreatic cell types in vivo and in vitro and their potential to serve as beta-cell progenitor.
引用
收藏
页码：995 / 1001
页数：7
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