Synthesis of aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers through the base-mediated reaction between phenols and halothane

被引：3

作者：

Karuo, Yukiko ^{[1
]}

Kametani, Ayaka ^{[1
]}

Tarui, Atsushi ^{[1
]}

Sato, Kazuyuki ^{[1
]}

Kawai, Kentaro ^{[1
]}

Omote, Masaaki ^{[1
]}

机构：

[1] Setsunan Univ, Fac Pharmaceut Sci, 45-1 Nagaotoge Cho, Hirakata, Osaka 5730101, Japan

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 17卷

关键词：

aryl 1,1-difluoroethyl ether; 1,1-difluoroethene; fluorine compound; halothane; phenol; NICKEL-CATALYZED FORMATION; BIS(2-METHOXYETHYL)AMINOSULFUR TRIFLUORIDE; REFORMATSKY REACTION; TETRAFLUOROETHYLENE; KETONES; CONSTRUCTION; FLUORINATION; DERIVATIVES; CYCLIZATION; INHIBITORS;

D O I：

10.3762/bjoc.17.9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and convenient method for the synthesis of structurally unique and highly functionalized aryl 2-bromo-2-chloro-1,1-difluoroethyl ethers has been developed. This approach exhibits a broad reaction scope, a simple operation and without the need of any expensive transition-metal catalyst, highly toxic or corrosive reagents. Notably, we demonstrate the potential utility of halothane for the synthesis of aryl gem-difluoroalkyl ethers containing the bromochloromethyl group.

引用

页码：89 / 96

页数：8

共 19 条

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