Transcriptional regulation of development in heterocyst-forming cyanobacteria

被引:66
作者
Flores, Enrique [1 ]
Picossi, Silvia [1 ]
Valladares, Ana [1 ]
Herrero, Antonia [1 ]
机构
[1] Univ Seville, CSIC, Inst Bioquim Vegetal & Fotosintesis, Seville, Spain
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2019年 / 1862卷 / 07期
关键词
STRAIN PCC 7120; INTERCELLULAR MOLECULAR-EXCHANGE; ANABAENA SP PCC-7120; SEPTAL PROTEIN SEPJ; SIGMA-FACTOR GENES; NITROGEN-FIXATION; DIAZOTROPHIC GROWTH; PATTERN-FORMATION; FERREDOXIN-NADP(+) REDUCTASE; CELL-DIFFERENTIATION;
D O I
10.1016/j.bbagrm.2018.04.006
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Filamentous, heterocyst-forming cyanobacteria are among the simplest multicellular systems in Nature. In the absence of combined nitrogen, the filaments consist of vegetative cells that fix CO2 through oxygenic photosynthesis and micro-oxic heterocysts specialized for the fixation of N-2 in a proportion of about 10 to 1. The development of a heterocyst-containing filament involves differentiation of vegetative cells into heterocysts in a process that requires a distinct gene expression program. Two transcription factors are strictly required, NtcA and HetR. The CRP-family protein NtcA directly activates the expression of multiple genes during heterocyst differentiation in some cases assisted by coactivators including HetR and in mature heterocysts, whereas HetR is needed to build high NtcA levels in differentiating heterocysts and directly activates some particular genes. A few other regulators of gene expression participate at specific differentiation steps, and a specific transcription factor, CnfR, activates nif gene expression under the micro-oxic conditions of the heterocyst.
引用
收藏
页码:673 / 684
页数:12
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