Biodegradable polyurethane PMeOx-PU(SS)-PMeOx micelles with redox and pH-sensitivity for efficient delivery of doxorubicin

被引：5

作者：

Zhang, Hena ^{[1
]}

Liu, Xiaojun ^{[1
]}

Xu, Kang ^{[1
]}

Du, Baixiang ^{[1
]}

Zhu, Caihong ^{[2
]}

Li, Yuling ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China

[2] Soochow Univ, Med Coll, Orthopaed Inst, Suzhou 215007, Peoples R China

来源：

EUROPEAN POLYMER JOURNAL | 2020年 / 140卷

基金：

中国国家自然科学基金;

关键词：

COPOLYMERS; POLY(2-METHYL-2-OXAZOLINE); POLYMER; DESIGN; LIPASE;

D O I：

10.1016/j.eurpolymj.2020.110054

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

In this paper, a new amphiphilic block polymer of polyoxazoline-polyurethane (PMeOx-PU(SS)-PMeOx) was prepared by introducing disulfide bonds into the polyurethane backbone and capping with polyoxazoline. This block polymer can be self-assembled in water to form polymer micelles with particle size of 163.1 +/- 0.5 nm. Using the antitumor drug doxorubicin (DOX) as a model drug, the drug release behaviour of drug-loaded micelles in a simulated intracellular environment was studied. The results indicated that the release of the drug can be stimulated in an acidic and reductive environment. The MTT test showed that the DOX-loaded PMeOx-PU(SS)-PMeOx micelles had high activity against C6 (rat glioma cells) cells, and the half-maximal inhibitory concentration (IC50) was 10.14 mu g/mL. These results indicated that pH and reductiondual-responsive PMeOx-PU(SS)-PMeOx DOX-loaded micelles have broad application prospects in the efficient release of intracellular hydrophobic anticancer drugs (98.21%) and in improving the therapeutic effect of cancer.

引用

页数：9