Recent Advances on the s-Triazine Scaffold with Emphasis on Synthesis, Structure-Activity and Pharmacological Aspects: A Concise Review

被引：20

作者：

Majeed Ganai, Ab ^{[1
]}

Khan Pathan, Tabasum ^{[1
]}

Hampannavar, Girish A. ^{[1
,2
]}

Pawar, Chandrakant ^{[1
]}

Obakachi, Vincent A. ^{[1
]}

Kushwaha, Babita ^{[1
]}

Deshwar Kushwaha, Narva ^{[1
]}

Karpoormath, Rajshekhar ^{[1
]}

机构：

[1] Univ KwaZulu Natal Westville, Coll Hlth Sci, Dept Pharmaceut Chem, Discipline Pharmaceut Sci, ZA-4000 Durban, South Africa

[2] KLEUs Coll Pharm, Dept Pharmaceut Chem, Hubli 580031, Karnataka, India

来源：

CHEMISTRYSELECT | 2021年 / 6卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

Anti-cancer; Anti-microbial; Anti-parasitic; SAR; s-Triazine; ONE-POT SYNTHESIS; SUBSTITUTED 1,3,5-TRIAZINES; STRAIGHTFORWARD SYNTHESIS; CATALYZED CYCLIZATION; BIOLOGICAL EVALUATION; DERIVATIVES; DESIGN; INHIBITORS; DISCOVERY; ALCOHOLS;

D O I：

10.1002/slct.202004591

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Triazine nuclei have occupied a propitious place in pharmaceutical chemistry due to their diverse biological behaviour. The marketed drugs such as Azacitidine, Melarsoprol, Altretamine and Almitrine display broad pharmacological activities like anti-cancer, anti-parasitic, anti-inflammatory, Respiratory stimulant and many more. Literature studies reveal that the 2, 4, and 6 substitution on s-triazine is important for varied biological activities. This diversity in pharmacological activities of triazine scaffold has fascinated the various researchers to further investigate its applications in the treatment of several diseases. This review is complementary to earlier reports and aims to review the work reported on various synthetic methods and biological activities of substituted s-triazine derivatives from 2016 to 2020 with a list of patents. The enriched structure-activity relationship may open the doors for further rational drug development of s-triazine containing analogues as good clinical candidates.

引用

页码：1616 / 1660

页数：45

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