Metastatic uveal melanoma - A morphologic and immunohistochemical analysis

被引:0
作者
Luyten, GPM
Mooy, CM
Post, J
Jensen, OA
Luider, TM
deJong, PTVM
机构
[1] ERASMUS UNIV ROTTERDAM,DEPT PATHOL,NL-3000 DR ROTTERDAM,NETHERLANDS
[2] UNIV COPENHAGEN,EYE PATHOL INST,COPENHAGEN,DENMARK
[3] NETHERLANDS OPHTHALM RES INST,NL-1100 AC AMSTERDAM,NETHERLANDS
关键词
uveal melanoma; metastasis; cell type; HMB-45; S-100; NKI-C3;
D O I
10.1002/(SICI)1097-0142(19961101)78:9<1967::AID-CNCR18>3.0.CO;2-W
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND. Uveal melanoma often metastasizes late and preferentially to the liver, in contrast to cutaneous melanoma. The objective of the current study was to evaluate the histopathologic and immunohistochemical changes in primary uveal melanomas and their corresponding metastases. METHODS. The morphology and immunohistochemical reactivity for the melanoma-associated antibodies HMB-45, S-100 protein, and NKI-C3 were assessed for 29 primary uveal melanomas and their corresponding metastases. RESULTS. A significant difference in cell type of the primary and the metastatic uveal melanoma was found (P = 0.0001). The metastases derived from the 29 patients revealed 82.5% epithelioid or nonclassifiable cells. Positive staining of the primary uveal melanomas and their metastases was found to be 93% and 91%, respectively, for HMB-45, 80% and 66%, respectively, for S-100, and 56% and 71%, respectively, for NKI-C3. CONCLUSIONS. Metastases of uveal melanomas are comprised of a higher grade of malignant cell types. Nonclassifiable cells can be observed in 40% of metastatic lesions. In the current study, HMB-45 proved to be the most sensitive immunohistochemical marker in the analysis of metastatic uveal melanoma and should be used as part of a panel of monoclonal antibodies in the analysis of any metastatic tumor of unknown origin. (C) 1996 American Cancer Society.
引用
收藏
页码:1967 / 1971
页数:5
相关论文
共 34 条
[1]  
BECKENKAMP G, 1988, EUR J CANCER CLIN ON, V24, pS41
[2]  
BURNIER MN, 1991, CANCER, V68, P809, DOI 10.1002/1097-0142(19910815)68:4<809::AID-CNCR2820680424>3.0.CO
[3]  
2-C
[4]   S-100 PROTEIN REMAINS A PRACTICAL MARKER FOR MELANOCYTIC AND OTHER TUMORS [J].
COCHRAN, AJ ;
LU, HF ;
LI, PX ;
SAXTON, R ;
WEN, DR .
MELANOMA RESEARCH, 1993, 3 (05) :325-330
[5]   PROGNOSTIC FACTORS FOLLOWING ENUCLEATION OF 111 UVEAL MELANOMAS [J].
COLEMAN, K ;
BAAK, JPA ;
VANDIEST, P ;
MULLANEY, J ;
FARRELL, M ;
FENTON, M .
BRITISH JOURNAL OF OPHTHALMOLOGY, 1993, 77 (11) :688-692
[6]   PREDICTIVE FACTORS OF VISUAL OUTCOME AFTER LOCAL RESECTION OF CHOROIDAL MELANOMA [J].
DAMATO, BE ;
PAUL, J ;
FOULDS, WS .
BRITISH JOURNAL OF OPHTHALMOLOGY, 1993, 77 (10) :616-623
[7]   IMMUNOHISTOCHEMICAL ANALYSIS OF CUTANEOUS MALIGNANT-MELANOMA - COMPARISON OF S-100 PROTEIN, HMB-45 MONOCLONAL-ANTIBODY AND NKI/C3 MONOCLONAL-ANTIBODY [J].
FERNANDO, SSE ;
JOHNSON, S ;
BATE, J .
PATHOLOGY, 1994, 26 (01) :16-19
[8]  
FUCHS U, 1992, AM J PATHOL, V141, P169
[9]  
GAMEL JW, 1993, CANCER, V71, P2299, DOI 10.1002/1097-0142(19930401)71:7<2299::AID-CNCR2820710721>3.0.CO
[10]  
2-G