Lysine acetylation in mitochondria: From inventory to function

被引:65
作者
Hosp, Fabian [1 ]
Lassowskat, Ines [2 ]
Santoro, Valeria [3 ]
De Vleesschauwer, David [4 ]
Fliegner, Daniela [5 ]
Redestig, Henning [4 ]
Mann, Matthias [1 ]
Christian, Sven [3 ]
Hannah, Matthew A. [4 ]
Finkemeier, Iris [2 ,6 ]
机构
[1] Max Planck Inst Biochem, Prote & Signal Transduct, Am Klopferspitz 18, D-82152 Martinsried, Germany
[2] Max Planck Inst Plant Breeding Res, Plant Prote, Carl Von Linne Weg 10, DE-50829 Cologne, Germany
[3] Bayer Pharma AG, Therapeut Res Grp Onc 2, Muellerstr 178, DE-13353 Berlin, Germany
[4] Bayer Cropsci NV, Technolpk 38, BL-9052 Ghent, Zwijnaarde, Belgium
[5] Bayer Pharma AG, Dept Heart & Lung Dis Res, Aprather Weg 18a, DE-42113 Wuppertal, Germany
[6] Univ Munster, Inst Plant Biol & Biotechnol, Plant Physiol, Schlosspl 7, DE-48149 Munster, Germany
关键词
Mitochondria; Lysine acetylation; Acetyl-CoA; Respiration; TCA cycle; ATP synthase; Arabidopsis; Rice; Human; Mouse; MEDIATED CELL-DEATH; PROTEIN ACETYLATION; POSTTRANSLATIONAL MODIFICATIONS; OXIDATIVE STRESS; CALORIE RESTRICTION; PROTEOMIC ANALYSIS; METABOLIC ENZYMES; HEART-FAILURE; MALONYL-COA; SIRT3;
D O I
10.1016/j.mito.2016.07.012
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cellular signaling pathways are regulated in a highly dynamic fashion in order to quickly adapt to distinct environmental conditions. Acetylation of lysine residues represents a central process that orchestrates cellular metabolism and signaling. In mitochondria, acetylation seems to be the most prevalent post-translational modification, presumably linked to the compartmentation and high turnover of acetyl-CoA in this organelle. Similarly, the elevated pH and the higher concentration of metabolites in mitochondria seem to favor non-enzymatic lysine modifications, as well as other acylations. Hence, elucidating the mechanisms for metabolic control of protein acetylation is crucial for our understanding of cellular processes. Recent advances in mass spectrometry-based proteomics have considerably increased our knowledge of the regulatory scope of acetylation. Here, we review the current knowledge and functional impact of mitochondrial protein acetylation across species. We first cover the experimental approaches to identify and analyze lysine acetylation on a global scale, we then explore both commonalities and specific differences of plant and animal acetylomes and the evolutionary conservation of protein acetylation, as well as its particular impact on metabolism and diseases. Important future directions and technical challenges are discussed, and it is pointed out that the transfer of knowledge between species and diseases, both in technology and biology, is of particular importance for further advancements in this field. (C) 2016 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
引用
收藏
页码:58 / 71
页数:14
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