Resonant Microbubble as a Microfluidic Stage for All-Optical Photoacoustic Sensing

被引:26
作者
Frigenti, Gabriele [1 ,2 ,3 ,4 ]
Cavigli, Lucia [3 ]
Fernandez-Bienes, Alberto [5 ]
Ratto, Fulvio [3 ]
Centi, Sonia [3 ]
Garcia-Fernandez, Tupak [6 ]
Conti, Gualtiero Nunzi [1 ,2 ,3 ]
Soria, Silvia [3 ]
机构
[1] Ctr Fermi, Museo Stor Fis, Piazza Viminale 1, I-00184 Rome, RM, Italy
[2] Ctr Fermi, Ctr Studi & Ric Enrico Fermi, Piazza Viminale 1, I-00184 Rome, RM, Italy
[3] CNR, Ist Fis Applicata Nello Carrara, Via Madonna Piano 10, I-50019 Sesto Fiorentino, FI, Italy
[4] Univ Firenze, Lab Europeo Spettroscopia Nonlineare, Via Nello Carrara 1, I-50019 Sesto Fiorentino, FI, Italy
[5] Univ Nacl Autonoma Mexico, Fac Ingn, Ciudad De Mexico 04510, Mexico
[6] Univ Autonoma Ciudad Mexico, Prolongac San Isidro 151, Ciudad De Mexico 09790, Mexico
关键词
ULTRASOUND DETECTION; FLOW-CYTOMETRY; MICROSCOPY;
D O I
10.1103/PhysRevApplied.12.014062
中图分类号
O59 [应用物理学];
学科分类号
摘要
We implement a whispering-gallery-mode microbubble resonator (MBR) as a multifunctional component for all-optical photoacoustic inspection of materials in a platform combining microfluidic design and high sensitivity to spectral absorbance. In our setup, the MBR acts both as the acoustic transducer and as the vial for a sample causing the photoacoustic event, thus dictating its operational frequency and removing any need for impedance-matching media. We challenge our setup in the assessment of the photostability of gold nanorods to demonstrate its validity. We develop a numerical model to qualitatively interpret the experimental signal as a transient shift of the resonance condition of the MBR. Possible implementations of the MBR in photoacoustic sensors are discussed.
引用
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页数:6
相关论文
共 29 条
[1]   High Q silica microbubble resonators fabricated by arc discharge [J].
Berneschi, S. ;
Farnesi, D. ;
Cosi, F. ;
Conti, G. Nunzi ;
Pelli, S. ;
Righini, G. C. ;
Soria, S. .
OPTICS LETTERS, 2011, 36 (17) :3521-3523
[2]   1064-nm-resonant gold nanorods for photoacoustic theranostics within permissible exposure limits [J].
Cavigli, Lucia ;
Centi, Sonia ;
Borri, Claudia ;
Tortoli, Paolo ;
Panettieri, Ilaria ;
Streit, Ingolf ;
Ciofini, Daniele ;
Magni, Giada ;
Rossi, Francesca ;
Siano, Salvatore ;
Ratto, Fulvio ;
Pini, Roberto .
JOURNAL OF BIOPHOTONICS, 2019, 12 (10)
[3]   Light activated microbubbles for imaging and microsurgery [J].
Cavigli, Lucia ;
Micheletti, Filippo ;
Tortoli, Paolo ;
Centi, Sonia ;
Lai, Sarah ;
Borri, Claudia ;
Rossi, Francesca ;
Ratto, Fulvio ;
Pini, Roberto .
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2017, 2017, 10064
[4]   Photostability of Gold Nanorods upon Endosomal Confinement in Cultured Cells [J].
Cavigli, Lucia ;
Cini, Alberto ;
Centi, Sonia ;
Borri, Claudia ;
Lai, Sarah ;
Ratto, Fulvio ;
de Angelis, Marella ;
Pini, Roberto .
JOURNAL OF PHYSICAL CHEMISTRY C, 2017, 121 (11) :6393-6400
[5]   Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods [J].
Cavigli, Lucia ;
Tatini, Francesca ;
Borri, Claudia ;
Ratto, Fulvio ;
Centi, Sonia ;
Cini, Alberto ;
Lelli, Beatrice ;
Matteini, Paolo ;
Pini, Roberto .
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2016, (111)
[6]   All-optical photoacoustic microscopy [J].
Chen, Sung-Liang ;
Guo, L. Jay ;
Wang, Xueding .
PHOTOACOUSTICS, 2015, 3 (04) :143-150
[7]   Spherical whispering-gallery-mode microresonators [J].
Chiasera, Alessandro ;
Dumeige, Yannick ;
Feron, Patrice ;
Ferrari, Maurizio ;
Jestin, Yoann ;
Conti, Gualtiero Nunzi ;
Pelli, Stefano ;
Soria, Silvia ;
Righini, Giancarlo C. .
LASER & PHOTONICS REVIEWS, 2010, 4 (03) :457-482
[8]   Resonance Frequency of Optical Microbubble Resonators: Direct Measurements and Mitigation of Fluctuations [J].
Cosci, Alessandro ;
Berneschi, Simone ;
Giannetti, Ambra ;
Farnesi, Daniele ;
Cosi, Franco ;
Baldini, Francesco ;
Conti, Gualtiero Nunzi ;
Soria, Silvia ;
Barucci, Andrea ;
Righini, Giancarlo ;
Pelli, Stefano .
SENSORS, 2016, 16 (09)
[9]   Confocal reflectance microscopy for determination of microbubble resonator thickness [J].
Cosci, Alessandro ;
Quercioli, Franco ;
Farnesi, Daniele ;
Berneschi, Simone ;
Giannetti, Ambra ;
Cosi, Franco ;
Barucci, Andrea ;
Conti, Gualtiero Nunzi ;
Righini, Giancarlo ;
Pelli, Stefano .
OPTICS EXPRESS, 2015, 23 (13) :16693-16701
[10]   Isometric multimodal photoacoustic microscopy based on optically transparent micro-ring ultrasonic detection [J].
Dong, Biqin ;
Li, Hao ;
Zhang, Zhen ;
Zhang, Kevin ;
Chen, Siyu ;
Sun, Cheng ;
Zhang, Han F. .
OPTICA, 2015, 2 (02) :169-176