Venetoclax as monotherapy and in combination with hypomethylating agents or low dose cytarabine in relapsed and treatment refractory acute myeloid leukemia: a systematic review and meta-analysis

被引：75

作者：

Bewersdorf, Jan Philipp ^{[1
]}

Giri, Smith ^{[2
]}

Wang, Rong ^{[3
,4
]}

Williams, Robert T. ^{[5
]}

Tallman, Martin S. ^{[6
]}

Zeidan, Amer M. ^{[1
,4
]}

Stahl, Maximilian ^{[6
]}

机构：

[1] Yale Sch Med, Sect Hematol, Dept Internal Med, New Haven, CT USA

[2] Univ Alabama Birmingham, Sch Med, Div Hematol & Oncol, Birmingham, AL USA

[3] Yale Univ, Canc Outcomes Publ Policy & Effectiveness Res COP, New Haven, CT USA

[4] Yale Univ, Sch Publ Hlth, Dept Chron Dis Epidemiol, New Haven, CT USA

[5] Rockefeller Univ, 1230 York Ave, New York, NY 10021 USA

[6] Mem Sloan Kettering Canc Ctr, Leukemia Serv, 1275 York Ave, New York, NY 10021 USA

来源：

HAEMATOLOGICA | 2020年 / 105卷 / 11期

基金：

美国国家卫生研究院;

关键词：

RECOMMENDATIONS; DIAGNOSIS; OUTCOMES; AML;

D O I：

10.3324/haematol.2019.242826

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：2659 / 2663

页数：5

共 15 条

[1] Association of leukemia genetics with response to venetoclax and hypomethylating agents in relapsed/refractory acute myeloid leukemia [J].

Aldoss, Ibrahim ;

Yang, Dongyun ;

Pillai, Raju ;

Sanchez, James F. ;

Mei, Matthew ;

Aribi, Ahmed ;

Ali, Haris ;

Sandhu, Karamjeet ;

Al Malki, Monzr M. ;

Salhotra, Amandeep ;

Khaled, Samer ;

Sun, Weili ;

O'Donnell, Margaret ;

Snyder, David ;

Nakamura, Ryotaro ;

Stein, Anthony S. ;

Forman, Stephen J. ;

Marcucci, Guido ;

Pullarkat, Vinod .

AMERICAN JOURNAL OF HEMATOLOGY, 2019, 94 (10) :E253-E255

[2] Revised recommendations of the international working group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia [J].

Cheson, BD ;

Bennett, JM ;

Kopecky, KJ ;

Büchner, T ;

Willman, CL ;

Estey, EH ;

Schiffer, CA ;

Döhner, H ;

Tallman, MS ;

Lister, TA ;

LoCocco, F ;

Willemze, R ;

Biondi, A ;

Hiddemann, W ;

Larson, RA ;

Löwenberg, B ;

Sanz, MA ;

Head, DR ;

Ohno, R ;

Bloomfield, CD .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (24) :4642-4649

[3] Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia [J].

DiNardo, Courtney D. ;

Pratz, Keith ;

Pullarkat, Vinod ;

Jonas, Brian A. ;

Arellano, Martha ;

Becker, Pamela S. ;

Frankfurt, Olga ;

Konopleva, Marina ;

Wei, Andrew H. ;

Kantarjian, Hagop M. ;

Xu, Tu ;

Hong, Wan-Jen ;

Chyla, Brenda ;

Potluri, Jalaja ;

Pollyea, Daniel A. ;

Letai, Anthony .

BLOOD, 2019, 133 (01) :7-17

[4] Clinical experience with the BCL2-inhibitor venetoclax in combination therapy for relapsed and refractory acute myeloid leukemia and related myeloid malignancies [J].

DiNardo, Courtney D. ;

Rausch, Caitlin R. ;

Benton, Christopher ;

Kadia, Tapan ;

Jain, Nitin ;

Pemmaraju, Naveen ;

Daver, Naval ;

Covert, Wendy ;

Marx, Kayleigh R. ;

Mace, Morgan ;

Jabbour, Elias ;

Cortes, Jorge ;

Garcia-Manero, Guillermo ;

Ravandi, Farhad ;

Bhalla, Kapil N. ;

Kantarjian, Hagop ;

Konopleva, Marina .

AMERICAN JOURNAL OF HEMATOLOGY, 2018, 93 (03) :401-407

[5] Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel [J].

Doehner, Hartmut ;

Estey, Elihu ;

Grimwade, David ;

Amadori, Sergio ;

Appelbaum, Frederick R. ;

Buechner, Thomas ;

Dombret, Herve ;

Ebert, Benjamin L. ;

Fenaux, Pierre ;

Larson, Richard A. ;

Levine, Ross L. ;

Lo-Coco, Francesco ;

Naoe, Tomoki ;

Niederwieser, Dietger ;

Ossenkoppele, Gert J. ;

Sanz, Miguel ;

Sierra, Jorge ;

Tallman, Martin S. ;

Tien, Hwei-Fang ;

Wei, Andrew H. ;

Lowenberg, Bob ;

Bloomfield, Clara D. .

BLOOD, 2017, 129 (04) :424-447

[6] The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions [J].

Downs, SH ;

Black, N .

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH, 1998, 52 (06) :377-384

[7] Clofarabine Plus Cytarabine Compared With Cytarabine Alone in Older Patients With Relapsed or Refractory Acute Myelogenous Leukemia: Results From the CLASSIC I Trial [J].

Faderl, Stefan ;

Wetzler, Meir ;

Rizzieri, David ;

Schiller, Gary ;

Jagasia, Madan ;

Stuart, Robert ;

Ganguly, Siddhartha ;

Avigan, David ;

Craig, Michael ;

Collins, Robert ;

Maris, Michael ;

Kovacsovics, Tibor ;

Goldberg, Stuart ;

Seiter, Karen ;

Hari, Parameswaran ;

Greiner, Jochen ;

Vey, Norbert ;

Recher, Christian ;

Ravandi, Farhad ;

Wang, Eunice S. ;

Vasconcelles, Michael ;

Huebner, Dirk ;

Kantarjian, Hagop M. .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (20) :2492-2499

[8] Very poor long-term survival in past and more recent studies for relapsed AML patients: The ECOG-ACRIN experience [J].

Ganzel, Chezi ;

Sun, Zhuoxin ;

Cripe, Larry D. ;

Fernandez, Hugo F. ;

Douer, Dan ;

Rowe, Jacob M. ;

Paietta, Elisabeth M. ;

Ketterling, Rhett ;

O'Connell, Michael J. ;

Wiernik, Peter H. ;

Bennett, John M. ;

Litzow, Mark R. ;

Luger, Selina M. ;

Lazarus, Hillard M. ;

Tallman, Martin S. .

AMERICAN JOURNAL OF HEMATOLOGY, 2018, 93 (08) :1074-1081

[9] Durable remissions with venetoclax monotherapy in secondary AML refractory to hypomethylating agents and high expression of BCL-2 and/or BIM [J].

Huemer, Florian ;

Melchardt, Thomas ;

Jansko, Bettina ;

Wahida, Adam ;

Jilg, Stefanie ;

Jost, Philipp J. ;

Klieser, Eckhard ;

Steiger, Katja ;

Magnes, Teresa ;

Pleyer, Lisa ;

Greil-Ressler, Sigrun ;

Rass, Christof ;

Greil, Richard ;

Egle, Alexander .

EUROPEAN JOURNAL OF HAEMATOLOGY, 2019, 102 (05) :437-441

[10] Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia [J].

Konopleva, Marina ;

Pollyea, Daniel A. ;

Potluri, Jalaja ;

Chyla, Brenda ;

Hogdal, Leah ;

Busman, Todd ;

McKeegan, Evelyn ;

Salem, Ahmed Hamed ;

Zhu, Ming ;

Ricker, Justin L. ;

Blum, William ;

DiNardo, Courtney D. ;

Kadia, Tapan ;

Dunbar, Martin ;

Kirby, Rachel ;

Falotico, Nancy ;

Leverson, Joel ;

Humerickhouse, Rod ;

Mabry, Mack ;

Stone, Richard ;

Kantarjian, Hagop ;

Letai, Anthony .

CANCER DISCOVERY, 2016, 6 (10) :1106-1117

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