Metabolic rewiring in melanoma

被引：127

作者：

Ratnikov, B. I. ^{[1
]}

Scott, D. A. ^{[1
]}

Osterman, A. L. ^{[1
]}

Smith, J. W. ^{[1
]}

Ronai, Z. A. ^{[1
]}

机构：

[1] Sanford Burnham Prebys Med Discovery Inst, Ctr Canc, 10901 North Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

ONCOGENE | 2017年 / 36卷 / 02期

关键词：

ENDOTHELIAL GROWTH-FACTOR; PYRUVATE-KINASE; GLUTAMINE-METABOLISM; MITOCHONDRIAL METABOLISM; ONCOMETABOLITE; 2-HYDROXYGLUTARATE; OXIDATIVE-PHOSPHORYLATION; CELLULAR ADAPTATION; METASTATIC MELANOMA; MALIGNANT-MELANOMA; GLUCOSE-METABOLISM;

D O I：

10.1038/onc.2016.198

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oncogene-driven metabolic rewiring is an adaptation to low nutrient and oxygen conditions in the tumor microenvironment that enables cancer cells of diverse origin to hyperproliferate. Aerobic glycolysis and enhanced reliance on glutamine utilization are prime examples of such rewiring. However, tissue of origin as well as specific genetic and epigenetic changes determines gene expression profiles underlying these metabolic alterations in specific cancers. In melanoma, activation of the mitogen-activated protein kinase (MAPK) pathway driven by mutant BRAF or NRAS is a primary cause of malignant transformation. Activity of the MAPK pathway, as well as other factors, such as HIF1 alpha, Myc and MITF, are among those that control the balance between non oxidative and oxidative branches of central carbon metabolism. Here, we discuss the nature of metabolic alterations that underlie melanoma development and affect its response to therapy.

引用

页码：147 / 157

页数：11

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