High-sensitivity cardiac troponin I in women with a history of early-onset preeclampsia

被引:6
作者
Muijsers, Hella E. C. [1 ]
Westermann, Dirk [2 ,3 ]
Birukov, Anna [4 ,5 ,6 ,7 ,8 ,9 ,10 ,11 ]
van der Heijden, Olivier W. H. [12 ]
Drost, Jose T. [13 ]
Kraeker, Kristin [4 ,5 ,6 ,7 ,8 ,9 ,10 ,11 ]
Haase, Nadine [4 ,5 ,6 ,7 ,8 ,9 ,10 ,11 ]
Mueller, Dominik N. [4 ,5 ,6 ,7 ,8 ,9 ,10 ,11 ]
Herse, Florian [4 ,5 ,6 ,7 ,8 ,10 ,11 ]
Maas, Angela H. E. M. [1 ]
Dechend, Ralf [4 ,5 ,6 ,7 ,8 ,9 ,10 ,11 ,14 ]
Zeller, Tanja [2 ,3 ]
Roeleveld, Nel [15 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, Geert Grootepl Zuid 10, NL-6525 GA Nijmegen, Netherlands
[2] Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Hamburg, Germany
[3] German Ctr Cardiovasc Res DZHK, Partner Site Hamburg Lubeck Kiel, Berlin, Germany
[4] Joint Cooperat Max Delbruck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany
[5] Charite Univ Med Berlin, Berlin, Germany
[6] Free Univ Berlin, Berlin, Germany
[7] Humboldt Univ, Berlin, Germany
[8] Berlin Inst Hlth, Berlin, Germany
[9] German Ctr Cardiovasc Res DZKH, Partner Site Berlin, Berlin, Germany
[10] Max Delbruck Ctr Mol Med, Helmholtz Assoc, Berlin, Germany
[11] Berlin Inst Hlth BIH, Berlin, Germany
[12] Radboud Univ Nijmegen, Dept Obstet & Gynecol, Med Ctr, Nijmegen, Netherlands
[13] Saxenburgh Grp, Dept Cardiol, Hardenberg, Netherlands
[14] HELIOS Klin, Dept Cardiol & Nephrol, Berlin, Germany
[15] Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Dept Hlth Evidence, Med Ctr, Nijmegen, Netherlands
关键词
blood pressure; cardiovascular risk; high-sensitivity cardiac troponin I; preeclampsia; CARDIOVASCULAR-DISEASE RISK; HYPERTENSIVE PREGNANCY; GENERAL-POPULATION; BLOOD-PRESSURE; PATHOPHYSIOLOGY; ATHEROSCLEROSIS; INFLAMMATION; BIOMARKERS; DISORDERS; EVENTS;
D O I
10.1097/HJH.0000000000002497
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Objective: Preeclampsia is associated with an elevated risk of cardiovascular disease later in life. Women with a history of preeclampsia are at risk of developing hypertension as well as ischemic heart disease. Identification of women at the highest risk is important to initiate preventive strategies. We investigated whether high-sensitivity cardiac troponin I (hs-cTnI) levels are associated with a history of early-onset preeclampsia, and with hypertension in these high-risk women. Methods: Approximately 9-10 years after pregnancy, hs-cTnI levels were measured for 339 women of the Preeclampsia Risk Evaluation in FEMales cohort, consisting of 177 women with a history of early-onset preeclampsia and 162 women with a previous uncomplicated index pregnancy. Associations were analyzed using several statistical tests and linear regression analysis. Results: The median hs-cTnI levels (IQR) were 2.50 ng/l (2.30) in women with a history of early-onset preeclampsia and 2.35 ng/l (2.50) in women without a history of preeclampsia, P = 0.53. Among women with a history of early-onset preeclampsia, the hs-cTnI levels were higher in women who were hypertensive compared with their normotensive counterparts (medians 2.60 versus 2.30; P = 0.03). In addition, blood pressure levels increased with increasing hs-cTnI levels. Conclusion: We did not find a difference in hs-cTnI levels between women with and without a history of early-onset preeclampsia. Nonetheless, hs-cTnI levels were statistically significantly higher in current hypertensive women with a history of preeclampsia compared with their normotensive counterparts. Therefore, hs-cTnI levels might improve risk prediction for women at the highest risk of cardiovascular disease.
引用
收藏
页码:1948 / 1954
页数:7
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