TiCl4-Mediated Baylis-Hillman and aldol reactions without the direct use of a Lewis base

被引：153

作者：

Li, GG ^{[1
]}

Wei, HX ^{[1
]}

Gao, JJ ^{[1
]}

Caputo, TD ^{[1
]}

机构：

[1] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 01期

关键词：

titanium(IV) chloride; Baylis-Hillman reaction; aldol reaction;

D O I：

10.1016/S0040-4039(99)01992-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

TiCl4-Mediated Baylis-Hillman and aldol reactions were developed without the direct use of a Lewis base. These processes involve the conjugate addition of TiCl4 to alpha,beta-unsaturated substrates followed by carbonyl coupling. Baylis-Hillman olefins were obtained when alpha,beta-unsaturated ketones were employed as the substrates, whereas beta-halogenated aldol products were generated with an alpha,beta-unsaturated N-acyl benzoxalinone as the Michael-type acceptor. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1 / 5

页数：5

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