Chemical characterization and anti-inflammatory activity of luteolin glycosides isolated from lemongrass

被引：62

作者：

Francisco, Vera ^{[1
,2
]}

Figueirinha, Artur ^{[2
,3
]}

Costa, Gustavo ^{[2
,4
]}

Liberal, Joana ^{[1
,2
]}

Lopes, Maria Celeste ^{[1
,4
]}

Garcia-Rodriguez, Carmen ^{[5
]}

Geraldes, Carlos F. G. C. ^{[1
,6
,7
]}

Cruz, Maria T. ^{[1
,4
]}

Batista, Maria T. ^{[2
,4
]}

机构：

[1] Univ Coimbra, Ctr Neurosci & Cell Biol, P-3000548 Coimbra, Portugal

[2] Univ Coimbra, Fac Pharm, Ctr Pharmaceut Studies, P-3000548 Coimbra, Portugal

[3] Polytech Inst Viseu, Dept Environm, P-3504510 Viseu, Portugal

[4] Univ Coimbra, Fac Pharm, P-3000548 Coimbra, Portugal

[5] Univ Valladolid, Inst Biol & Genet Mol, CSIC, Valladolid 47003, Spain

[6] Univ Coimbra, Coimbra Chem Ctr, P-3004535 Coimbra, Portugal

[7] Univ Coimbra, Fac Sci & Technol, Dept Life Sci, P-3001401 Coimbra, Portugal

来源：

JOURNAL OF FUNCTIONAL FOODS | 2014年 / 10卷

关键词：

Cymbopogon citratus; Lemongrass; Flavonoids; Luteolin; Glycosylation; Anti-inflammatory; CYMBOPOGON-CITRATUS LEAVES; BIOLOGICAL-ACTIVITY; IMMUNE-SYSTEM; KAPPA-B; INHIBITION; FLAVONOIDS; INFLAMMATION; POLYPHENOLS; MACROPHAGES; TARGET;

D O I：

10.1016/j.jff.2014.07.003

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Flavonoids from lemongrass - Cymbopogon citratus (DC.) Stapf - leaves infusion, a commonly consumed beverage for the treatment of inflammatory-related conditions, were investigated in this work. Luteolin O-, C- and O,C-glycosides were isolated and identified by nuclear magnetic resonance, being the cassiaoccidentalin B structure fully characterized for the first time in lemongrass. The anti-inflammatory activity of luteolin and its glycosides was evaluated in lipopolysaccharide-stimulated macrophages. Luteolin glycosides demonstrated less cytotoxicity than luteolin itself. Although glycosylation decreases luteolin anti-inflammatory properties, being higher to C-glycosylation, an inhibitory effect on inflammatory mediator production (nitric oxide and IL-1 beta) was verified for the luteolin 7-O-beta-glucopyranoside, without cytotoxic effects. Therefore, luteolin glycosides from lemongrass infusion are evidenced as a less toxic alternative to current anti-inflammatory drugs with promising use in pharmaceutical and food supplement industries. Additionally, this work establishes structure activity relationships, which constitutes valuable information in the design of anti-inflammatory luteolin glycosides devoid of toxicity. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：436 / 443

页数：8

共 30 条

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