Vaccines for COVID-19: perspectives from nucleic acid vaccines to BCG as delivery vector system

被引：18
作者：
de Queiroz, Nina Mari G. P. [1 ]
Marinho, Fabio V. [1 ]
Chagas, Marcelo A. [1 ]
Leite, Luciana C. C. [2 ]
Homan, E. Jane [3 ]
de Magalhaes, Mariana T. Q. [1 ]
Oliveira, Sergio C. [1 ,4 ]
机构：
[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil
[2] Inst Butantan, Lab Desenvolvimento Vacinas, Sao Paulo, SP, Brazil
[3] ioGenetics LLC, Madison, WI USA
[4] CNPq MCT, Inst Nacl Ciencia & Tecnol Doencas Trop INCT DT, Salvador, BA, Brazil
来源：
MICROBES AND INFECTION | 2020年 / 22卷 / 10期
基金：
巴西圣保罗研究基金会; 美国国家卫生研究院;
关键词：
COVID-19; SARS-CoV-2; RBD domain; Vaccines; BCG; ACUTE RESPIRATORY SYNDROME; T-CELL RESPONSES; HUMAN MONOCLONAL-ANTIBODIES; ADAPTIVE IMMUNE-RESPONSES; SARS-CORONAVIRUS; CALMETTE-GUERIN; FUNCTIONAL RECEPTOR; TRAINED IMMUNITY; EBOLA VACCINE; PROTECTS MICE;
D O I：
10.1016/j.micinf.2020.09.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This article discusses standard and new disruptive strategies in the race to develop an anti-COVID-19 vaccine. We also included new bioinformatic data from our group mapping immunodominant epitopes and structural analysis of the spike protein. Another innovative approach reviewed here is the use of BCG vaccine as priming strategy and/or delivery system expressing SARS-CoV-2 antigens. (C) 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：515 / 524
页数：10
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