Incidentally detected prostate cancer in patients undergoing radical cystoprostatectomy

Objectives: To review all features of incidentally discovered prostate adenocarcinoma in patients who underwent radical cystoprostatectomy for bladder urothelial carcinoma. Cystoprostatectomy specimens obtained from patients with bladder cancer provide a unique opportunity to assess the features of silent prostate adenocarcinoma (PCa). Materials and Methods: Sixty-eight male bladder cancer patients who underwent radical cystoprostatectomy at our center between January 2010 and December 2012 were included in this study. The mean age of the patients was 63.18 years (range: 47-78 years). Prostate of all patients were embedded and sectioned at 2-mm intervals. Two uropathologist examined the prostatic tissues from radical cystoprostatectomy specimens. Results: Incidentally prostate cancer was found in 26/68 (38.23%) of cystoprostatectomy specimens. All were acinar adenocarcinoma. Of these, 16 (61.54%) were located in the peripheral zone. 22 cases (84.61%) was stage pT(2). Gleason score was 6 or less in 16 (61.54%) patients. Negative margins were present in 96.15% of cases. All cases were pN(0) for PCa. Conclusions: The occurrence of incidentally prostate cancer in radical cistoprostatectomy specimens in Romania is similar to Western countries. For those who are candidates for prostate-sparing surgery, it is indicate to include a routine prostate biopsy.