Synthesis of 5-alkylidene-1,3-dioxane-4,6-diones, an easily accessible family of axially chiral alkenes: preparation in non-racemic form and platinum binding studies

被引：3

作者：

Casadesus, Meritxell ^{[1
]}

Coogan, Michael P. ^{[1
]}

Ooi, Li-Ling ^{[1
]}

机构：

[1] Cardiff Univ, Dept Chem, Cardiff CF10 3TB, Wales

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 20期

关键词：

D O I：

10.1039/b608785j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general synthetic route to 5-alkylidene-1,3-dioxane-4,6-diones, which are a family of axially chiral alkenes, is described. Conformational issues are explored and the platinum-binding properties of these species are discussed. That these alkenes exist as stable enantiomers is established by their partial kinetic resolution upon reaction with cysteine.

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页码：3822 / 3830

页数：9

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