Engineering β-sheet peptide assemblies for biomedical applications

被引:82
|
作者
Yu, Zhiqiang [1 ]
Cai, Zheng [1 ]
Chen, Qiling [1 ]
Liu, Menghua [1 ]
Ye, Ling [1 ]
Ren, Jiaoyan [2 ]
Liao, Wenzhen [2 ]
Liu, Shuwen [1 ]
机构
[1] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China
[2] S China Univ Technol, Dept Food Sci & Technol, Wushan Rd 381, Guangzhou 510641, Guangdong, Peoples R China
关键词
SELF-COMPLEMENTARY OLIGOPEPTIDE; CONTROLLED-RELEASE; NANOFIBER SCAFFOLDS; SUSTAINED-RELEASE; POTENTIAL CARRIER; IN-SITU; CELL; DELIVERY; HYDROGELS; PROTEINS;
D O I
10.1039/c5bm00472a
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Hydrogels have been widely studied in various biomedical applications, such as tissue engineering, cell culture, immunotherapy and vaccines, and drug delivery. Peptide-based nanofibers represent a promising new strategy for current drug delivery approaches and cell carriers for tissue engineering. This review focuses on the recent advances in the use of self-assembling engineered beta-sheet peptide assemblies for biomedical applications. The applications of peptide nanofibers in biomedical fields, such as drug delivery, tissue engineering, immunotherapy, and vaccines, are highlighted. The current challenges and future perspectives for self-assembling peptide nanofibers in biomedical applications are discussed.
引用
收藏
页码:365 / 374
页数:10
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