The neurobiological basis of autism from a developmental perspective

被引：89
作者：
Akshoomoff, N [1 ]
Pierce, K [1 ]
Courchesne, E [1 ]
机构：
[1] Childrens Hosp, Res Ctr, Lab Res Neurosci Autism, La Jolla, CA 92037 USA
来源：
DEVELOPMENT AND PSYCHOPATHOLOGY | 2002年 / 14卷 / 03期
关键词：
D O I：
10.1017/S0954579402003115
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Autism is a neurobiological disorder that is diagnosed through careful behavioral assessment in early childhood. In this paper, we review recent studies that have attempted to reveal the underlying causes of autism using a variety of techniques. Particular emphasis is placed on techniques that have been used by a number of different laboratories, including structural magnetic resonance imaging and postmortem studies of neuroanatomy. Neurobiological and neuropsychological data from individuals across a wide age range are examined from a neurodevelopmental perspective. We discuss how these recent advances have led us to develop a growth dysregulation hypothesis of autism. Finally, we discuss how this hypothesis may lead to new innovations in autism research.
引用
收藏
页码：613 / 634
页数：22
相关论文
共 123 条
[1]  
Akshoomoff N, 2000, COMM LANG INTERVEN, V9, P167
[2]  
AKSHOOMOFF N, 2001, INT M AUT RES SAN DI
[3]  
AKSHOOMOFF NA, 1997, INT REV NEUROBIOLOGY, V41
[4]  
ANDREASEN NC, 1993, AM J PSYCHIAT, V150, P130
[5]  
[Anonymous], 1989, Autism: Nature, diagnosis, and treatment
[6]   MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults [J].
Aylward, EH ;
Minshew, NJ ;
Goldstein, G ;
Honeycutt, NA ;
Augustine, AM ;
Yates, KO ;
Barta, PE ;
Pearlson, GD .
NEUROLOGY, 1999, 53 (09) :2145-2150
[7]   A clinicopathological study of autism [J].
Bailey, A ;
Luthert, P ;
Dean, A ;
Harding, B ;
Janota, I ;
Montgomery, M ;
Rutter, M ;
Lantos, P .
BRAIN, 1998, 121 :889-905
[8]   From first words to grammar in children with focal brain injury [J].
Bates, E ;
Thal, D ;
Trauner, D ;
Fenson, J ;
Aram, D ;
Eisele, J ;
Nass, R .
DEVELOPMENTAL NEUROPSYCHOLOGY, 1997, 13 (03) :275-343
[9]  
Bauman M.L., 1994, NEUROBIOLOGY AUTISM, P119
[10]  
BAYER SA, 1993, NEUROTOXICOLOGY, V14, P83
12345678910