Tissue Engineering Strategies for Intervertebral Disc Treatment Using Functional Polymers

被引:38
作者
Choi, Youngjoo [1 ]
Park, Min Hee [2 ]
Lee, Kangwon [1 ,3 ]
机构
[1] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Transdisciplinary Studies, Seoul 08826, South Korea
[2] Korea Inst Ceram Engn & Technol, Ctr Convergence Bioceram Mat, Cheongju 28160, South Korea
[3] Adv Inst Convergence Technol, Gyeonggi Do 16229, South Korea
基金
新加坡国家研究基金会;
关键词
tissue engineering; functional polymers; intervertebral disc; degenerative disc; regeneration; MESENCHYMAL STEM-CELLS; HUMAN NUCLEUS PULPOSUS; ANNULUS FIBROSUS; EXTRACELLULAR-MATRIX; HYALURONIC-ACID; CROSS-LINKING; IN-VITRO; MECHANICAL-PROPERTIES; PROGENITOR CELLS; ORGAN-CULTURE;
D O I
10.3390/polym11050872
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Intervertebral disc (IVD) is the fibrocartilage between the vertebrae, allowing the spine to move steadily by bearing multidirectional complex loads. Aging or injury usually causes degeneration of IVD, which is one of the main reasons for low back pain prevalent worldwide and reduced quality of life. While various treatment strategies for degenerative IVD have been studied using in vitro studies, animal experiments, and clinical trials, there are unsolved limitations for endogenous regeneration of degenerative IVD. In this respect, several tissue engineering strategies that are based on the cell and scaffolds have been extensively researched with positive outcomes for regeneration of IVD tissues. Scaffolds made of functional polymers and their diverse forms mimicking the macro- and micro-structure of native IVD enhance the biological and mechanical properties of the scaffolds for IVD regeneration. In this review, we discuss diverse morphological and functional polymers and tissue engineering strategies for endogenous regeneration of degenerative IVD. Tissue engineering strategies using functional polymers are promising therapeutics for fundamental and endogenous regeneration of degenerative IVD.
引用
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页数:25
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