A Supramolecular Approach for Preparation of Size-Controlled Nanoparticles

被引：167

作者：

Wang, Hao ^{[1
]}

Wang, Shutao ^{[1
]}

Su, Helen ^{[1
]}

Chen, Kuan-Ju ^{[1
]}

Armijo, Amanda Lee ^{[1
]}

Lin, Wei-Yu ^{[1
]}

Wang, Yanju ^{[1
]}

Sun, Jing ^{[1
]}

Kamei, Ken-ichiro ^{[1
]}

Czernin, Johannes ^{[1
]}

Radu, Caius G. ^{[1
]}

Tseng, Hsian-Rong ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Inst Mol Med, CIMI,CNSI, Los Angeles, CA 90095 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 24期

关键词：

adamantanes; biodistribution; cyclodextrins; nanoparticles; positron emission tomography; NANOTECHNOLOGY; DELIVERY; DESIGN; DRUG;

D O I：

10.1002/anie.200900063

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A supramolecular approach has been developed for the preparation of supramolecular nanoparticles (SNPs) with variable sizes (30-450 nm) from three different molecular building blocks using a cyclodextrin/adamantane recognition system. Positron emission tomography (PET) was employed to study the biodistribution and lymph node drainage of the SNPs in mice. The sizes of the SNPs affect their in vivo characteristics (see picture). © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：4344 / 4348

页数：5

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