Photothermal effects in connective tissues mediated by laser-activated gold nanorods

被引：73

作者：

Ratto, Fulvio ^{[1
]}

Matteini, Paolo ^{[1
]}

Rossi, Francesca ^{[1
]}

Menabuoni, Luca ^{[2
]}

Tiwari, Neha ^{[3
]}

Kulkarni, Sulabha K. ^{[3
]}

Pini, Roberto ^{[1
]}

机构：

[1] CNR, Ist Fis Applicata, Sesto Fiorentino, Italy

[2] Unita Operativa Oculist, Prato, Italy

[3] Univ Pune, Dept Phys, DST Unit Nanosci, Pune, Maharashtra, India

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2009年 / 5卷 / 02期

关键词：

Gold nanorods; Laser-activated nanoparticles; Laser-tissue interactions; Laser welding; Photothermal effects; NANOPARTICLES; ABSORPTION; ALBUMIN; COLLAGEN; THERAPY; SOLDER; TEMPERATURE; SENSITIVITY; PARAMETERS; SCATTERING;

D O I：

10.1016/j.nano.2008.10.002

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

We report a study on the application of laser-activated nanoparticles in the direct welding of connective tissues, which may become a valuable technology in biomedicine. We use colloidal gold nanorods as new near-infrared chromophores to mediate functional photothermal effects in the eye lens capsules. Samples obtained ex vivo from porcine eyes are treated to simulate heterotransplants with 810-nm diode laser radiation in association with a stain of gold nanorods of aspect ratio approximately 4. This stain is applied at the interface between a patch of capsule from a donor eye and the capsule of a recipient eye. Then, by administration of laser pulses of 40 msec and approximately 100-140 J/cm(2), we achieved the local denaturation of the endogenous collagen filaments, which reveals that the treated area reached temperatures above 50 degrees C. The thermal damage is confined within 50-70 mu m in a radial distance from the irradiated area. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：143 / 151

页数：9

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