Urinary NGAL Marks Cystic Disease in HIV-Associated Nephropathy

被引：43

作者：

Paragas, Neal ^{[1
]}

Nickolas, Thomas L. ^{[1
]}

Wyatt, Christina ^{[2
]}

Forster, Catherine S. ^{[1
]}

Sise, Meghan ^{[1
]}

Morgello, Susan ^{[2
]}

Jagla, Bernd ^{[1
]}

Buchen, Charles ^{[1
]}

Stella, Peter ^{[1
]}

Sanna-Cherchi, Simone ^{[1
]}

Carnevali, Maria Luisa ^{[3
]}

Mattei, Silvia ^{[3
]}

Bovino, Achiropita ^{[3
]}

Argentiero, Lucia ^{[3
]}

Magnano, Andrea ^{[3
]}

Devarajan, Prasad ^{[4
]}

Schmidt-Ott, Kai M. ^{[5
]}

Allegri, Landino ^{[3
]}

Klotman, Paul ^{[2
]}

D'Agati, Vivette ^{[1
]}

Gharavi, Ali G. ^{[1
]}

Barasch, Jonathan ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, New York, NY 10032 USA

[2] Mt Sinai Sch Med, New York, NY USA

[3] Univ Parma, I-43100 Parma, Italy

[4] Cincinnati Childrens Hosp, Med Ctr, Cincinnati, OH USA

[5] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2009年 / 20卷 / 08期

基金：

美国国家卫生研究院;

关键词：

GELATINASE-ASSOCIATED LIPOCALIN; ACUTE KIDNEY INJURY; ANTIRETROVIRAL THERAPY; HIV-1-ASSOCIATED NEPHROPATHY; INFECTED PATIENTS; IN-VITRO; EPIDEMIOLOGY; CELLS; GLOMERULOSCLEROSIS; ACCUMULATION;

D O I：

10.1681/ASN.2009010065

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Nephrosis and a rapid decline in kidney function characterize HIV-associated nephropathy (HIVAN). Histologically, HIVAN is a collapsing focal segmental glomerulosclerosis with prominent tubular damage. We explored the expression of neutrophil gelatinise-associated lipocalin (NGAL), a marker of tubular injury, to determine whether this protein has the potential to aid in the noninvasive diagnosis of HIVAN. We found that expression of urinary NGAL was much higher in patients with biopsy-proven HIVAN than in HIV-positive and HIV-negative patients with other forms of chronic kidney disease. In the HIV-transgenic mouse model of HIVAN, NGAL mRNA was abundant in dilated, microcystic segments of the nephron. In contrast, urinary NGAL did not correlate with proteinuria in human or in mouse models. These data show that marked upregulation of NGAL accompanies HIVAN and support further study of uNGAL levels in large cohorts to aid in the noninvasive diagnosis of HIVAN and screen for HIVAN-related tubular damage.

引用

页码：1687 / 1692

页数：6

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